Evidence map›Paper›PMID 41694580›Full record

ArticleInternational journal of biological sciences2026

NOX4-derived oxidative DNA damage impairs thyroid differentiation through an epigenetic mechanism in BRAF-mutated radioactive iodine refractory papillary thyroid cancer cells.

Mickaëlle Radom, Camille Buffet, Juliana Cazarin, Marylin Harinquet, Caroline Coelho de Faria, Floriane Brayé, Catline Nobre, Marine Aglave, Yasmina Mesloub, Thibault Dayris and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Mickaëlle RadomUMR 9019 CNRS, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
Camille BuffetSorbonne Université, Service de Pathologies Thyroïdiennes et Tumeurs endocrines, Groupe de Recherche Clinique n°16 Tumeurs Thyroïdiennes, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.
Juliana CazarinUMR 9019 CNRS, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
Marylin HarinquetUMR 9019 CNRS, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
Caroline Coelho de FariaUMR 9019 CNRS, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
Floriane BrayéINSERM U981, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
Catline NobreINSERM U981, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
Marine AglaveBioinformatics Plateform, Gustave Roussy, Villejuif, France.
Yasmina MesloubBioinformatics Plateform, Gustave Roussy, Villejuif, France.
Thibault DayrisBioinformatics Plateform, Gustave Roussy, Villejuif, France.
Nathalie DroinAMMICa Platform, INSERM US23, CNRS UAR 3655, Gustave Roussy, Villejuif, France.
Karine GodefroyCancer Medical Pathology and Biology Department, Gustave Roussy, Villejuif, France.
Mohamed-Amine BaniCancer Medical Pathology and Biology Department, Gustave Roussy, Villejuif, France.
Abir Al GhuzlanUMR 9019 CNRS, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
Sophie LeboulleuxDepartment of Endocrinology and Diabetology, Hôpitaux Universitaires de Genève, Geneve, Switzerland.
Livia LamartinaCancer Medicine Department, Gustave Roussy, Université Paris Saclay, Villejuif, France.
Corinne DupuyUMR 9019 CNRS, Gustave Roussy, Université Paris-Saclay, Villejuif, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radioiodine (RAI) therapy, used for treating differentiated thyroid cancers (DTCs), hinges on the functional expression of the sodium-iodide symporter (NIS). However, up to 60% of papillary thyroid carcinomas, the most common DTC subtype, harbor BRAF

Indexed as

DNA DamageNADPH Oxidase 4Proto-Oncogene Proteins B-rafThyroid Cancer, PapillaryThyroid NeoplasmsCell DifferentiationCell Line, TumorEpigenesis, GeneticHumansIodine RadioisotopesMutationReactive Oxygen SpeciesThyroid GlandBRAF protein, humanIodine RadioisotopesNADPH Oxidase 4NOX4 protein, humanProto-Oncogene Proteins B-rafReactive Oxygen SpeciesBRAFV600ENADPH oxidaseOxidative DNA damageRadioiodine refractory thyroid cancer.ROS

Identifiers

PMID41694580
PMCPMC12905579

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.