Evidence map›Paper›PMID 41694618›Full record

ArticlebioRxiv : the preprint server for biology2025

Tumor-Derived Polyamines Initiate Fat Wasting in Cancer Cachexia.

Matias Fabregat, Rachel J Fenske, Julia K Hansen, Cameron J Kaminsky, Jevin Lortie, Alexander Nassar, Kayla Kressin, Annie Jen, Lucia Cilloni, Katherine Overmeyer and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Matias FabregatDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Rachel J FenskeDepartment of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Julia K HansenDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Cameron J KaminskyDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
Jevin LortieDepartment of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Alexander NassarDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
Kayla KressinDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Annie JenIntegrated Program in Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Lucia CilloniDepartment of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Katherine OvermeyerDepartment of Biomolecular Chemistry, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Caroline M AlexanderMcArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, USA.
John W GarrettDepartment of Radiology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Perry J PickhardtDepartment of Radiology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Joshua J CoonDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
Costas A LyssiotisDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Marina Pasca di MaglianoRogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
Lingjun LiDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
Adam J KuchniaDepartment of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Andrea GalmozziDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.ORCID 0000-0002-9411-7327

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
TR&D 2 Metabolic Labels for Ultraplexed Protein Quantification p. 453P41GM108538 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI COON, JOSHUA J · 2016 to 2025
$13.1M
Project 3: Modulation of the head and neck tumor immune microenvironment by targeting the TAM family of receptorsP50CA278595 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Zachary Scott Morris · 2022 to 2026
$12.5M
Structure, Function and Regulation of the ProteomeR35GM118110 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI COON, JOSHUA J · 2016 to 2025
$9.1M
Biotechnology Training ProgramT32GM135066 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI SCOTT M. COYLE, BRIAN G FOX · 2020 to 2026
$7.0M
Mass Spectrometric Studies of Neuropeptides in FeedingR01DK071801 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI LINGJUN LI · 2006 to 2026
$6.7M
Creating a region- specific biomolecular atlas of the brain of Alzheimer’s diseaseR01AG078794 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LINGJUN LI, Luigi Puglielli · 2022 to 2026
$3.7M
DiLeu-enabled multiplexed quantitation for biomarker discovery and validation in Alzheimer’s diseaseR01AG052324 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LINGJUN LI · 2023 to 2026
$2.3M
Acquisition of a High-Field Dual Source FTICR-MS for Pharmaceutical ResearchS10RR029531 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2011 to 2011
$2.1M
Dissecting intracellular metabolite trafficking using chemoproteomicsR35GM150899 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Andrea Galmozzi · 2023 to 2026
$1.6M
Acquisition of a Dual-Source, High-Performance, Ion Mobility, Quadrupole Time-of-Flight Mass Spectrometry System for Biomedical Research at UW-MadisonS10OD028473 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2021 to 2021
$1.3M
NCATS NIH HHS UL1 TR002373NCI NIH HHS P30 CA014520NCI NIH HHS P50 CA278595NCRR NIH HHS S10 RR029531NIA NIH HHS R01 AG052324NIA NIH HHS R01 AG078794NIDDK NIH HHS R01 DK071801NIGMS NIH HHS P41 GM108538NIGMS NIH HHS R35 GM118110NIGMS NIH HHS R35 GM150899NIGMS NIH HHS T32 GM135066NIH HHS S10 OD025084NIH HHS S10 OD028473
6 · The paper itself

Abstract

Cancer-associated cachexia (CC) is a fatal metabolic condition characterized by progressive loss of fat and muscle mass, yet its early molecular drivers remain poorly defined. Here, we identify a polyamine-dependent tumor-adipose crosstalk that triggers adipocyte lipolysis and fat wasting during the pre-cachexia stage, preceding systemic inflammation and muscle atrophy. Cancer-derived polyamines are enriched in extracellular vesicles and promote lipid mobilization via eIF5A hypusination, independent of adrenergic signaling. In preclinical models, polyamine accumulation associates with early fat loss and elevated circulating fatty acids. Clinically, automated CT imaging of newly diagnosed pancreatic cancer patients reveals increased adipose density, reflecting lipolysis, that correlates with circulating polyamine levels and predicts poor survival. These findings support polyamine metabolism as a mechanistic driver and candidate biomarker of early cachexia, providing a framework for early detection and targeted intervention.

Identifiers

PMID41694618
PMCPMC12900250

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.