ArticleCurrent developments in nutrition2026
Foods Fortified with Soybean or Palm Oil Show No Effect on Inflammation or Oxidized Low-Density Lipoprotein in Adults with Overweight or Obesity: a Secondary Analysis of a Randomized Placebo-Controlled Crossover Trial.
Article in Current developments in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04975763 (Dietary Oils to Sustain Energy), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dietary Oils to Sustain Energy (DOSE) Study: Understanding How Consumption of Dietary Oils in Foods Influences Blood Fatty Acids and Body Weight
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Popular and social media outlets have recent posts claiming that vegetable and seed oils high in linoleic acid (LA) cause inflammation and oxidative stress. However, substantial evidence in the scientific literature shows LA biomarkers are associated with lower risks for type 2 diabetes, cardiovascular disease, and systemic inflammation. Objectives: The primary aim of this study is to evaluate the impact of dietary fortification with soybean oil (high in LA) compared with palm oil on markers of systemic inflammation and oxidized low-density lipoprotein (oxLDL) in healthy overweight adult participants. Methods: This double-masked crossover clinical trial consisted of 2 diet periods where adults with overweight or obesity were randomly assigned to receive 3 study foods delivering 30 g oil/d of either soybean or palm oil for 4-wk periods. During a 2-wk wash-out period, participants refrained from consuming study foods. Erythrocyte and plasma fatty acid composition, blood biomarkers of systemic inflammation and oxLDL, desaturase indices, and body weights were measured at each study visit. Results: After 4 wk of consuming 30 g/d of soybean or palm oil snacks, most inflammatory markers and oxLDL remained unchanged. However, interleukin-6 showed a trend toward reduction in the soybean oil group ( Conclusions: Incorporating study foods containing 30 g oil/d of soybean or palm oil had no significant impact on inflammatory markers, suggesting that higher LA intake is not proinflammatory as is stated in popular media outlets. In addition, a two week washout period may be sufficient for dietary oil interventions in crossover study designs.This trial was registered at clinicaltrials.gov as NCT04975763.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.