ArticleCase reports in pediatrics2026
Recognizing Pathogenic PVCs in Children: A Case of Multifocal Ectopic Purkinje-Related Premature Contractions.
Article in Case reports in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Recognizing Pathogenic PVCs in Children: A Case of Multifocal Ectopic Purkinje-Related Premature Contractions.Case reports in pediatrics · 2026Article
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7 authors.
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Abstract
Premature ventricular contractions (PVCs) are a common and benign arrhythmia in children, but they can infrequently be a sign of an underlying cardiac issue that may predispose patients to heart failure and/or sudden cardiac death (SCD). A 13-year-old, otherwise, healthy female presented for a routine annual evaluation and was found to have an irregular heartbeat. Initial ECGs showed frequent multiform PVCs, premature junctional contractions (PJCs), and short nonsustained runs of ventricular tachycardia (NSVT). PVCs were characterized by sharp initial QRS deflection and relatively narrow QRS duration pointing toward an origin from the Purkinje system. Inpatient 24-h Holter monitor showed frequent multiform PVCs and short runs of NSVT with a 48% burden. Echocardiogram showed a structurally normal heart but moderately depressed left ventricular function. Family history was positive for several individuals on the paternal side who experienced SCD and cardiomyopathy. Specifically, her paternal aunt had symptomatic multiform PVCs which have been refractory to multiple antiarrhythmic medications and catheter ablations. Her aunt's genetic testing was significant for a variant of uncertain significance (VUS) in
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