ArticleFrontiers in veterinary science2025
Ameliorative effects of vitamin C and garlic (
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Nifedipine, a calcium channel blocker widely prescribed for hypertension, has been implicated in oxidative stress-mediated reproductive toxicity. This study investigated the ameliorative effects of vitamin C and garlic ( Methods: Twenty-five adult male rats were randomized into control and treatment groups, receiving nifedipine (0.571 mg/kg) alone or in combination with vitamin C (200 mg/kg) and/or garlic extract (200 mg/kg) for 40 days. Reproductive parameters and histopathological changes in the testes and epididymis were assessed. Results: Nifedipine administration significantly reduced sperm parameters compared to control-sperm motility (38.9 ± 2.53 vs. 83.25 ± 1.65 in controls, Conclusion: Nifedipine caused significant impairments in sperm quality and histological integrity. Vitamin C and garlic combination produced a statistically significant improvement in normal sperm morphology, with other parameters showing non-significant numerical increases. Further research with larger sample sizes and biochemical analyses is needed to clarify the extent of antioxidant influence on nifedipine-induced reproductive alterations.
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