ArticlePulmonary circulation2026
Association of Immunoglobulin E With Right Ventricular Dysfunction in Pulmonary Arterial Hypertension.
Article in Pulmonary circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Amb a 1-Specific IgE in Heart Failure: A Translational Framework for Seasonal Risk, Endotyping, and Patient-Centered Management.Journal of clinical medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulmonary arterial hypertension (PAH) is characterized by pulmonary vasoconstriction and vascular remodeling, leading to increased pulmonary vascular resistance, pathological right ventricular (RV) remodeling, and ultimately right heart failure and death. RV function and right ventricle-pulmonary artery (RV-PA) coupling are critical determinants of patient prognosis, and echocardiography remains the preferred tool for assessing RV function and predicting RV-PA coupling. Recent studies have revealed that immunoglobulin E(IgE) plays a regulatory role in cardiac and pulmonary vascular remodeling; however, its role in PAH-related RV dysfunction remains unclear. This study aimed to investigate the association between serum IgE levels and RV dysfunction in patients with PAH through echocardiography, serological testing, and right heart catheterization (RHC), to provide potential evidence for novel diagnostic and therapeutic strategies in PAH. A total of 30 patients diagnosed with idiopathic pulmonary arterial hypertension (IPAH) at the First Affiliated Hospital of Chinese Guangxi Medical University between 2024 and 2025 were prospectively enrolled, along with an equal number of age- and sex-matched individuals with normal cardiac function and no cardiopulmonary disease as controls. Clinical baseline data and serum samples were collected from all participants, and serum IgE concentrations were determined using enzyme-linked immunosorbent assay (ELISA). For IPAH patients, serum N-terminal pro-brain natriuretic peptide (NT-proBNP) levels, RHC parameters, and World Health Organization (WHO) functional class were obtained from the electronic medical record system. Transthoracic echocardiography (TTE) was performed to assess RV morphology, structural characteristics, and functional alterations. Statistical analysis was performed using
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Registered trials
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