Evidence map›Paper›PMID 41695282›Full record

ArticleWorld journal of gastroenterology2026

Endocrine-liver bidirectional regulation: From mechanistic research to multidisciplinary clinical practice.

Kai-Rui Wan, Cheng Qian, Li-Mei Liu

Abstract readLetter
In one paragraph

Article in World journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kai-Rui WanSchool of Medicine, Chongqing University, Chongqing 400030, China.
Cheng QianSchool of Medicine, Chongqing University, Chongqing 400030, China.
Li-Mei LiuSchool of Medicine, Chongqing University, Chongqing 400030, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A close bidirectional regulatory network exists between endocrine disorders and liver dysfunction, and their reciprocal imbalance is a key driver of metabolic liver diseases and chronic liver diseases. Based on the review, this letter systematically appraises its value in elucidating bidirectional crosstalk mechanisms across the thyroid, parathyroid, pancreas, adrenal, and sex hormone axes with the liver, while identifying limitations in mechanistic depth and clinical translation. Aligned with current clinical needs and research hotspots, we propose targeted research directions, including strengthening multi-omics biomarker screening, optimizing individualized management for special populations, and refining interdisciplinary collaboration, so as to provide comprehensive theoretical support and practical references for multidisciplinary team diagnosis and treatment of endocrine-related liver diseases.

Indexed as

Endocrine System DiseasesLiverLiver DiseasesBiomarkersHumansReview Literature as TopicBiomarkersEndocrine systemHormonal imbalanceLiver functionMetabolic liver diseaseMultidisciplinary team

Identifiers

PMID41695282
PMCPMC12898411

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.