Evidence map›Paper›PMID 41695297›Full record

ArticleWellcome open research2025

An oropharyngeal gonorrhoea controlled human infection model: a provisional protocol using a novel

Eloise Williams, Georgina L Pollock, David J Price, Tim Crocker-Buque, Dana de Kretser, Euzebiusz Jamrozik, Joshua Osowicki, Shivani Pasricha, Francesca Azzato, Andrew Steer and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Wellcome open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Eloise WilliamsDepartment of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia.ORCID https://orcid.org/0000-0002-5654-896X
Georgina L PollockDepartment of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia.
David J PriceDepartment of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia.
Tim Crocker-BuqueDepartment of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia.
Dana de KretserDepartment of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia.
Euzebiusz JamrozikDepartment of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia.
Joshua OsowickiTropical Diseases Research Group, Murdoch Children's Research Institute, Melbourne, Victoria, 3000, Australia.ORCID https://orcid.org/0000-0002-9432-6700
Shivani PasrichaDepartment of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia.ORCID https://orcid.org/0000-0001-9681-1956
Francesca AzzatoVictorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia.
Andrew SteerTropical Diseases Research Group, Murdoch Children's Research Institute, Melbourne, Victoria, 3000, Australia.
Joanna R GroomThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, 3000, Australia.
Danika L HillDepartment of Immunology, Monash University, Monash University, Clayton, Victoria, 3000, Australia.
Jason A RobertsUniversity of Queensland Centre for Clinical Research, University of Queensland, Brisbane, Queensland, 4000, Australia.
Wilhelmina M HustonFaculty of Science, The University of Melbourne, Melbourne, Victoria, 3000, Australia.
Kate L SeibInstitute for Biomedicine and Glycomics, Griffith University, Gold Coast, Queensland, 4222, Australia.
Christopher K FairleyMelbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, 3000, Australia.
Eric Pf ChowMelbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, 3000, Australia.
Marcus Y ChenMelbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, 3000, Australia.
Jane S HockingSexual Health Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, 3000, Australia.
Deborah A WilliamsonDepartment of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia.
James S McCarthyDepartment of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia.ORCID https://orcid.org/0000-0001-6596-9718

Funding

Wellcome Trust
6 · The paper itself

Abstract

Introduction: Gonorrhoea is a sexually transmissable infection caused by Methods and analysis: This dose-escalation CHIM study will enrol 20-35 healthy adult volunteers aged 18 to 50 years who were assigned male at birth and only have sex with people assigned male at birth. The primary objectives are to determine i) the safety and tolerability of an oropharyngeal gonorrhoea CHIM; and, ii) the minimum infectious dose of isolate AUSMDU00053933 required for 60-80% of participants to develop oropharyngeal Ethics and dissemination: After scientific peer review of this provisional protocol, a detailed protocol will be submitted for human research ethics committee assessment. Protocol development was informed by feedback from community engagement. Study findings will be disseminated in peer-reviewed journals and at scientific meetings, with summaries provided to relevant stakeholders.

Indexed as

antimicrobial resistanceControlled human infection modelgonorrhoeasexually transmitted infectionstudy protocolvaccine

Identifiers

PMID41695297
PMCPMC12902672

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.