Evidence map›Paper›PMID 41695490›Full record

ArticleTheranostics2026

Why 11β-HSD1 inhibitors show variable efficacy in Alzheimer's therapy: an APOE4-dependent HSD11B1 mechanism.

RaiHua Lai, FengShiun Shie, RenHua Chung, Paul WeiChe Hsu, YiChung Chen, KaHei Lam, JyhLyh Juang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

RaiHua LaiNational Center for Geriatrics and Welfare Research, National Health Research Institutes, 35, Keyan Road, Zhunan Town, Miaoli 350401, Taiwan.
FengShiun ShieCenter for Neuropsychiatric Research, National Health Research Institutes, 35, Keyan Road, Zhunan Town, Miaoli 350401, Taiwan.
RenHua ChungInstitute of Population Health Science, National Health Research Institutes, 35, Keyan Road, Zhunan Town, Miaoli 350401, Taiwan.
Paul WeiChe HsuInstitute of Molecular and Genomic Medicine, National Health Research Institutes, 35, Keyan Road, Zhunan Town, Miaoli 350401, Taiwan.
YiChung ChenNational Center for Geriatrics and Welfare Research, National Health Research Institutes, 35, Keyan Road, Zhunan Town, Miaoli 350401, Taiwan.
KaHei LamInstitute of Biochemistry and Molecular Biology, China Medical University, No. 100, Section 1, Jingmao Road, Taichung 406040, Taiwan.
JyhLyh JuangInstitute of Biochemistry and Molecular Biology, China Medical University, No. 100, Section 1, Jingmao Road, Taichung 406040, Taiwan.

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

11-beta-Hydroxysteroid Dehydrogenase Type 1Alzheimer DiseaseApolipoprotein E4Enzyme InhibitorsAgedAged, 80 and overAnimalsBrainFemaleGenetic Association StudiesHumansHydrocortisoneMaleMice11-beta-Hydroxysteroid Dehydrogenase Type 1Apolipoprotein E4Enzyme InhibitorsHSD11B1 protein, humanHydrocortisoneAlzheimer's diseaseAPOE4cortisol metabolismentorhinal cortexHSD11B1

Identifiers

PMID41695490
PMCPMC12905795

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.