Evidence map›Paper›PMID 41695491›Full record

ReviewTheranostics2026

From 2D cultures to 3D systems: evolving cancer models at the interface of functional precision medicine and theranostics.

Yizheng Zhang, Naray Payab, Bettina Weigelin, Christian M Schürch

Abstract readReview
In one paragraph

Review in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yizheng ZhangDepartment of Pathology and Neuropathology, University Hospital and Comprehensive Cancer Center Tübingen, Tübingen, Germany.
Naray PayabDepartment of Pathology and Neuropathology, University Hospital and Comprehensive Cancer Center Tübingen, Tübingen, Germany.
Bettina WeigelinWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tübingen, Germany.
Christian M SchürchDepartment of Pathology and Neuropathology, University Hospital and Comprehensive Cancer Center Tübingen, Tübingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advances in patient-derived cancer models are pushing precision oncology by linking functional testing directly to therapeutic decision-making. Traditional two-dimensional (2D) cancer cell culture systems have long served as accessible tools for studying cancer biology and drug responses, but their inability to replicate the complexity of the tumor microenvironment limits their translational value. In recent years, advances in culture and imaging technologies have enabled the development of three-dimensional (3D) cancer models, such as spheroids, organoids, and patient-derived explants, that more accurately represent tumor architecture and behavior

Indexed as

Cell Culture TechniquesCell Culture Techniques, Three DimensionalNeoplasmsPrecision MedicineTheranostic NanomedicineAnimalsHumansOrganoidsSpheroids, CellularTumor Microenvironmentcancer-on-a-chipcell culturefunctional precision medicineorganoidsPDXspheroidstumor explantstumor microenvironment

Identifiers

PMID41695491
PMCPMC12905781

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.