Evidence map›Paper›PMID 41695499›Full record

ArticleHeart rhythm O22026

Causality of atrial fibrillation and left atrial traits: Genetic and epigenetic perspectives.

Dihui Cai, Jie Xu, Yuheng Jiao, Yinyin Shen, Yingying Liao, Wei Han

Abstract read
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In one paragraph

Article in Heart rhythm O2, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dihui CaiDepartment of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Jie XuDepartment of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Yuheng JiaoDepartment of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Yinyin ShenDepartment of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Yingying LiaoDepartment of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Wei HanDepartment of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Atrial fibrillation (AF) is associated with left atrial (LA) abnormalities, yet the causality between them is not well defined. Objective: This study aimed to investigate the genetic correlations and bidirectional causality between AF and LA traits. Methods: We used genome-wide association study (GWAS) data from FinnGen and other cohorts. Linkage disequilibrium score regression was applied for estimates of genetic correlations, and Mendelian randomization (MR) analysis was conducted for causality analysis. Results: Linkage disequilibrium score regression revealed significant genetic correlations between LA traits and AF. Forward MR analyses established causal associations of AF on LA active emptying fraction (LAaEF) (β = -0.092; Conclusion: LAaEF is bidirectionally causally linked with AF, underscoring its importance in the management of AF. Epigenetic modifications, as evidenced by specific CpG sites, may contribute to atrial remodeling in AF, offering new avenues for research into the AF pathophysiology.

Indexed as

Atrial fibrillationEpigenetic modificationsHeart failureLeft atrial functionMendelian randomizationStroke

Identifiers

PMID41695499
PMCPMC12902232

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.