Evidence map›Paper›PMID 41695673›Full record

ArticleJournal of animal science and technology2026

Transcriptomic profiling of porcine duodenal, jejunal, and ileal organoids in response to porcine epidemic diarrhea virus.

Jiyoung Heo, Jae Han Park, Hyun Sung Park, Dong-Hoon Chae, Aaron Yu, Keonwoo Cho, Dong Ha Bhang, Yoo Yong Kim, Mi-Kyung Oh, Kyung-Rok Yu

Abstract read
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In one paragraph

Article in Journal of animal science and technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiyoung HeoDepartment of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea.ORCID https://orcid.org/0009-0001-7271-6708
Jae Han ParkDepartment of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea.ORCID https://orcid.org/0009-0003-8995-1944
Hyun Sung ParkDepartment of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea.ORCID https://orcid.org/0009-0008-8210-2823
Dong-Hoon ChaeDepartment of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea.ORCID https://orcid.org/0009-0007-7002-2992
Aaron YuDepartment of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea.ORCID https://orcid.org/0009-0003-0731-7422
Keonwoo ChoDepartment of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea.ORCID https://orcid.org/0009-0006-2235-942X
Dong Ha BhangAttislab Inc., Anyang 14059, Korea.ORCID https://orcid.org/0000-0002-6727-4036
Yoo Yong KimDepartment of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea.ORCID https://orcid.org/0000-0001-8121-3291
Mi-Kyung OhDepartment of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea.ORCID https://orcid.org/0009-0009-7678-0027
Kyung-Rok YuDepartment of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea.ORCID https://orcid.org/0000-0002-4685-3223

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Porcine epidemic diarrhea virus (PEDV) is a highly pathogenic virus that causes severe gastrointestinal disease in neonatal piglets, often leading to high mortality. To better understand PEDV pathogenesis, we developed porcine intestinal apical-out organoids derived from the duodenum, jejunum, and ileum that support viral replication and enable long-term experimental manipulation. In this study, we investigated the region-specific responses of these organoids to PEDV infection, focusing on regional characteristics, gene expression, and susceptibility to infection. PEDV replicated efficiently in the apical-out organoids, with significantly higher viral loads in jejunal and ileal organoids than duodenal organoids, indicating region-specific susceptibility. Bulk RNA sequencing and a differential gene expression analysis revealed unique transcriptomic responses across regions. The jejunal and ileal organoids exhibited stronger activation of pathways related to cellular processes, immune regulation, and antiviral defense than the duodenal organoids. Notably, viral entry receptor genes such as

Indexed as

Gene expression profilingPorcine epidemic diarrhea virus (PEDV)Porcine intestinal organoidsRegion-specific responsesViral pathogenesis

Identifiers

PMID41695673
PMCPMC12902409

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.