ArticleWorld journal of gastrointestinal surgery2026
Patterns and risk factors of early recurrence after radical resection for intrahepatic cholangiocarcinoma.
Article in World journal of gastrointestinal surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Early recurrence prediction after curative-intent surgery of intrahepatic cholangiocarcinoma using a novel weighted tumor burden score.World journal of surgical oncology · 2026Article
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5 authors.
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Abstract
backgroundIntrahepatic cholangiocarcinoma (ICC) represents the second-most prevalent primary hepatic malignancy, demonstrating increasing worldwide occurrence. Although surgical methods have progressed, outcomes following curative resection remain suboptimal due to substantial recurrence frequencies. Recurrence occurring early, usually during the initial postoperative year, indicates aggressive tumor characteristics and predicts inferior outcomes compared with delayed recurrence. Comprehending patterns and predictive indicators of early relapse is essential for refining postoperative monitoring approaches and directing adjuvant treatment choices. The present investigation concentrated on determining risk indicators and recurrence characteristics to enhance personalized patient management strategies for ICC.
aimTo determine the characteristics and predictive indicators of early disease recurrence following curative surgical resection of ICC.
methodsWe conducted a retrospective evaluation of 386 consecutive individuals who received curative surgical resection for ICC at our institution during the period spanning January 2017 through December 2021. Early disease recurrence was operationally defined as tumor relapse occurring within the first 12 postoperative months. Predictive indicators were examined through univariate and multivariate Cox proportional hazards regression analyses.
resultsWithin our cohort of 386 individuals, 237 patients (61.4%) demonstrated disease recurrence throughout the observation period, with 178 cases (75.1%) manifesting early recurrence. The predominant anatomical locations of recurrent disease included hepatic tissue (66.7%), regional lymph nodes (18.1%), and peritoneal surfaces (8.0%). Independent predictive indicators of early recurrence encompassed: Neoplasm diameter exceeding 5 cm [hazard ratio (HR) = 2.14, 95% confidence interval (CI): 1.52-3.01,
conclusionEarly disease recurrence following ICC resection occurs frequently and correlates with unfavorable clinical outcomes. Several neoplasm-associated and treatment-associated characteristics predict early relapse. These indicators can facilitate identification of patients at elevated risk who might benefit from intensive monitoring protocols or adjuvant therapeutic interventions.
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