ArticleFrontiers in pharmacology2025
Molecular features of prenylated (iso)flavonoids from Fabaceae in relation to their potential NorA inhibition in
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Multifunctional Curcumin-Inspired 3,5-Diarylidene-4-Piperidones: Design, Synthesis, Biological Evaluation and Computational Mechanistic Studies.Pharmaceuticals (Basel, Switzerland) · 2026Article
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5 authors.
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Abstract
Background: The overexpression of the NorA efflux pump is known to be an important factor in the antimicrobial resistance mechanism of Methods: A collection of 37 prenylated isoflavonoids and flavonoids (obtained by purification, chemically synthesized, or commercially purchased), collectively referred to as (iso)flavonoids, was evaluated for its activity against Results: Seven prenylated (iso)flavonoids, namely, 8-prenylnaringenin, 6- Conclusion: In our study, we provide, for the first time, predictive QSAR models of prenylated (iso)flavonoids as potential NorA inhibitors and propose two potential leads based on this family of plant-derived compounds. Future research on the specificity and validation of prenylated (iso)flavonoids as NorA inhibitors is required.
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