ArticleJournal of pregnancy2026
Evaluation of Serum Lactate Dehydrogenase and Electrolyte Levels Among Preeclamptic Women at the University of Gondar Comprehensive Specialized Hospital, Northwest, Ethiopia: A Comparative Cross-Sectional Study.
Article in Journal of pregnancy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Serum lactate dehydrogenase is a sensitive marker of hypoxia and cellular damage/death in preeclampsia due to vascular endothelial dysfunction. Evaluation of serum electrolytes can also indicate the severity of preeclampsia since it is a vascular endothelial disorder. However, in Ethiopia, there is a lack of data regarding the serum levels of lactate dehydrogenase and electrolytes among preeclamptic patients in comparison with apparently healthy normotensive pregnant women. Method: A hospital-based comparative cross-sectional study was conducted with 128 participants (64 preeclamptic women and 64 apparently healthy normotensive pregnant women) from October 20, 2021 to January 3, 2022. Preeclamptic women were further classified into 32 without severe features and 32 with severe features. Blood samples (5 mL) were collected, and a Beckman Coulter 700 AU chemistry analyzer was used to measure serum LDH and electrolyte levels. The data were analyzed using SPSS version 25. One-way ANOVA was run to examine the mean variations, and the receiver operator characteristic curve was used to determine the potential diagnostic value for preeclampsia. A Result: Preeclamptic women showed a statistically significant elevation of LDH ( Conclusion: Serum LDH was significantly increased in the preeclamptic group compared with normotensive controls. There were significantly decreased levels of serum electrolytes (magnesium, calcium, and potassium) in preeclamptic women. Therefore, it is better to focus on the measurement of serum LDH and electrolytes for early detection and effective management of preeclampsia.
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