Evidence map›Paper›PMID 41696142›Full record

ArticleBioactive materials2026

Heart-homed nanomedicine induces fast mitochondrial rescue to enhance cardiac function post-myocardial infarction.

Weimin Qi, Jue Wang, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Wenxuan Zheng, Min Liu, Shusheng Deng, Qiong Huang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Weimin QiDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha, 410008, China.
Jue WangXiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410013, China.
Shuya WangXiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410013, China.
Xiaojing ShiXiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410013, China.
Tingli XiongXiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410013, China.
Ruishi LiXiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410013, China.
Wenxuan ZhengXiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410013, China.
Min LiuDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha, 410008, China.
Shusheng DengCollege of Pharmacy, Xinjiang Medical University, Urumqi, 830017, China.
Qiong HuangDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha, 410008, China.
Jianhua LiuDepartment of Radiology, The Second Hospital of Jilin University, Changchun, 130041, China.
Kelong AiXiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410013, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In myocardial infarction (MI), mitochondrial dysfunction acts as a core mechanism linking energy failure to multiple downstream pathological processes, ultimately determining cardiomyocyte fate and cardiac function. However, the rapid and safe restoration of cardiomyocyte mitochondrial function remains a major challenge in MI therapy. Herein, we present a heart-homed fast acting mitochondrial-function enhancer (H-FAME), rationally engineered to achieve sequential targeting from ischemic myocardial tissue to cardiomyocyte mitochondria. By synergistically modulating mitochondrial membrane potential (MMP) and oxidative stress, H-FAME stabilizes mitochondrial function, thereby attenuating cardiomyocyte loss, inflammation, and fibrosis and ultimately promoting functional recovery after MI. In summary, H-FAME provides a robust approach for energy homeostasis restoration, and lays the foundation for the development of related mitochondrial protective drugs to treat MI.

Indexed as

Mitochondrial functionMyocardial infarctionOxidative stressUncoupling protein 2

Identifiers

PMID41696142
PMCPMC12905785

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.