ArticleJournal of biomedical optics2026
Optical coherence tomography and elastography for
Article in Journal of biomedical optics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
11 authors.
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Abstract
Significance: Stomach (gastric) cancer survival depends significantly on the stage in which it is detected, and surveillance with white light endoscopy exhibits poor contrast between gastric cancer and healthy tissue, especially at early stages. Early gastric cancer can exhibit changes in epithelial microstructure, including loss of regular gastric pit structure and collagen alterations which increase tissue stiffness. Aim: To improve contrast between early cancer and normal tissue, we investigate the use of optical coherence tomography (OCT) and elastography (OCE) to visualize changes in tissue structure and stiffness consistent with gastric cancer. Approach: Images of eight samples of Results: OCT image volumes showed more distinct gastric pit and tissue layer structure, as well as less optical attenuation, in normal tissue compared to gastric metaplasia and focal signet ring cell carcinoma (SRCC). Exemplary OCE-derived stress maps showed a trend of increasing measured stress with progression of precancer (metaplasia and dysplasia) and SRCC, suggesting increased tissue stiffness. Conclusions: This proof-of-concept study provides evidence that OCT and OCE may be capable of visualizing differences in tissue structure and stiffness between normal, metaplastic, dysplastic, and early cancerous gastric tissue, potentially providing the basis for improved screening tools with higher sensitivity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.