Evidence map›Paper›PMID 41696579›Full record

ReviewFrontiers in molecular biosciences2026

Non-coding RNA transcripts and their exosomal counterparts in the pathogenesis, diagnosis, and treatment of skin cancers, with a focus on melanoma.

Linjing Zou, Xuemei Wen, Xiyan Dai, Yaguang Wu

Abstract readReview
In one paragraph

Review in Frontiers in molecular biosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Linjing ZouThe First Affiliated Hospital of Army Military Medical University, Chongqing, China.
Xuemei WenThe First Affiliated Hospital of Army Military Medical University, Chongqing, China.
Xiyan DaiThe First Affiliated Hospital of Army Military Medical University, Chongqing, China.
Yaguang WuThe First Affiliated Hospital of Army Military Medical University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skin malignancies, including melanoma and non-melanoma cancers, are the most common cancers worldwide, with increasing incidence and fatality rates. Malignant melanoma (MM) is a highly aggressive cancer with poor prognosis, and despite various therapies, it remains a serious threat due to factors like tumor recurrence, drug resistance, and lack of effective treatments. Non-coding RNAs (ncRNAs) transcripts have gained attention due to their critical roles in regulating proliferation, angiogenesis, immune regulation, invasion, metastasis, and treatment resistance. Exosomes, biologically active lipid-bilayer extracellular vesicles secreted by various cell types, are also involved in cancer by carrying multiple bioactive molecules, including ncRNAs. Investigating the noncoding components of the transcriptome and their exosomal counterparts opens up the possibility of discovering new therapeutic and diagnostic targets. This review discusses current studies on the involvement of ncRNAs and their exosomal counterparts in the pathogenesis, diagnosis, and treatment of human skin cancers, particularly melanoma.

Indexed as

diagnosisexosomesmelanomanon-coding RNAsskin cancertherapeutictargets

Identifiers

PMID41696579
PMCPMC12894016

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.