ArticleGut microbes reports2025
A novel ketogenic diet that reduces seizures and prevents liver steatosis leads to related gut microbiome changes and restores cecal short-chain fatty acid levels in the rapid kindling rat model of epileptogenesis.
Article in Gut microbes reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Gut-Brain Axis Modulation by Short-Chain Fatty Acids Exerts Disease-Modifying Effects in a Murine Model of Drug-Resistant Epilepsy.Annals of neurology · 2026Article
- Selected Molecular Targets for Counteracting Epileptogenesis: What Do We Know About Its Effective Inhibition?Current issues in molecular biology · 2026Review
- Correlation of preoperative gut microbiota and postoperative delirium in patients undergoing minimally invasive direct coronary artery bypass grafting.Frontiers in microbiology · 2026Article
- Aging, the microbiota-gut-brain axis, and late-life epilepsy: a hypothesis-driven review.Frontiers in molecular neuroscience · 2026Review
Corrections and comments
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Authors and funding
11 authors.
Funding
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Abstract
We recently introduced an innovative ketogenic diet (KD) demonstrating superior antiseizure efficacy in a rat kindling model of epileptogenesis without inducing hepatic steatosis compared to a classic KD. This new diet features reduced fat content, lower plasma ketosis levels, and incorporates new ingredients, including a novel fermentable fiber blend, omega-3 polyunsaturated fatty acids (PUFAs) that partially replace omega-6 PUFAs, and medium-chain fatty acids that partially substitute for stearic acid. In the present study, we conducted gut microbiota analyses on cecum samples to elucidate its contribution to these effects. The analysis revealed distinctive features compared to the classic KD and control diet: higher weighted alpha diversity, distinct beta diversity, increased
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Registered trials
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