Evidence mapPaperPMID 41696643Full record

ArticleTherapeutic advances in drug safety2026

Donor and recipient genetic polymorphisms modulate tacrolimus pharmacokinetics during voriconazole co-therapy: a drug-drug interaction study in liver transplant recipients.

Jieling Li, Liubing Li, Yanzhe Xia, Jie Chen, Jiali Li, Xiaobin Lin, Xiao Chen, Ke-Jing Tang, Pan Chen, Xiaoman Liu

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Article in Therapeutic advances in drug safety, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Jieling LiDepartment of Pharmacy, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.ORCID https://orcid.org/0000-0003-2532-0652
Liubing LiDepartment of Laboratory Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Yanzhe XiaDepartment of Pharmacy, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Jie ChenDepartment of Pharmacy, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Jiali LiInstitute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Xiaobin LinDepartment of Pharmacy, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Xiao ChenDepartment of Pharmacy, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Ke-Jing TangDepartment of Pharmacy, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Pan ChenDepartment of Pharmacy, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Xiaoman LiuDepartment of Pharmacy, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.ORCID https://orcid.org/0000-0001-9879-9540

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: While recipient cytochrome P450 (CYP) genetic polymorphisms are established modulators of tacrolimus (TAC) pharmacokinetics, the combined effects of donor-derived hepatic and recipient intestinal Objectives: This study evaluated the impact of donor and recipient Design: A retrospective study was conducted on 139 liver transplant patients receiving TAC-based immunosuppressive therapy at the First Affiliated Hospital of Sun Yat-sen University from December 2016 to June 2025. Methods: The liver transplant recipients were stratified into a VRC co-therapy group ( Results: During VRC co-therapy, dual donor-recipient Conclusion: In summary, Donor and recipient

Indexed as

drug–drug interactionliver transplantationpharmacogeneticspharmacokineticstacrolimusvoriconazole

Identifiers

PMID41696643
PMCPMC12901897

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.