ArticleInvestigative radiology2026
3D Simultaneous Post-contrast T1/T2 Mapping and Synthetic Multi-Contrast Late Gadolinium Enhancement at 0.55T: Validation in Porcine Myocardial Infarction Model.
Article in Investigative radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo propose and validate a simplified method for 3D simultaneous post-contrast parametric mapping and synthetic late gadolinium enhancement (LGE) imaging at 0.55T for comprehensive whole-heart myocardial tissue characterization. MATERIALS AND
methodsA 3D joint T1/T2 mapping research sequence is adopted from a previous study. Three interleaved volumes with inversion recovery (IR) preparation, no magnetization preparation, and T2 preparation were acquired with image navigators to enable 100% respiratory scan efficiency. Intrinsically co-registered 3D T1, T2, and proton density maps were calculated using a dictionary-matching method, and Bloch equation-based IR and T2 preparation-IR (T2IR) signal models were proposed to generate multi-contrast 3D synthetic LGE images. In vivo evaluation included 10 data sets from a porcine myocardial infarction model to validate the performance of the proposed 3D method in comparison with that of separately scanned 2D reference sequences including post-contrast T1 mapping, pre-contrast T2 mapping, and LGE.
resultsFor the 10 swine data sets, 2D and 3D T1/T2 maps had consistent findings regarding the changes in T1/T2 values of myocardial infarction, presenting significantly decreased post-contrast T1 (2D: 279±48 vs. 472±44 ms, P <0.01; 3D: 355±32 vs. 597±48 ms, P <0.01) and increased T2 (2D: 102.4±11.5 vs. 66.4±3.1 ms, P <0.01; 3D: 71.0±5.3 vs. 39.4±4.5 ms, P <0.01) in scar compared with remote myocardium. 3D multi-contrast LGE images were successfully generated without additional scan and provided excellent image contrasts. Compared with 2D LGE, 3D synthetic bright-blood IR-LGE had improved scar-to-myocardium contrast ( P <0.01) with comparable image contrasts of scar-to-blood ( P =0.08) and blood-to-myocardium ( P =0.71), synthetic gray-blood IR-LGE had improved scar-to-blood and scar-to-myocardium contrast ( P <0.01) with comparable blood-to-myocardium contrast ( P =0.06), whereas synthetic dark-blood T2IR-LGE demonstrated significant differences regarding all tissue contrasts ( P <0.01).
conclusionsThe proposed method provided imaging findings consistent with 2D references and shows promise for comprehensive myocardial tissue characterization in a single simple scan.
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