ArticleEpilepsia2026
Rhythms in longitudinal thalamic recordings are linked to seizure risk.
Article in Epilepsia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Gamma suppression correlates with thalamic stimulation therapeutic response in intractable epilepsy.Epilepsia · 2026Article
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Abstract
objectiveSeizure unpredictability remains a major clinical challenge for people with epilepsy. Previous works have shown that seizure risk is associated with circadian and multi-day cycles in both brain and physiological signals. However, it remains unclear whether neural activity from deep brain structures such as the anterior nucleus of the thalamus (ANT), the only U.S. Food and Drug Administration (FDA)-approved deep-brain stimulation (DBS) target for treating medication-resistant epilepsy, exhibits similar cyclic modulation related to seizures. This study aimed to assess whether long-term local field potential (LFP) recordings from the ANT exhibit circadian and multi-day cycles that are associated with seizures that could be used to support seizure forecasting in a retrospective approach.
methodsSeven participants implanted with the Medtronic Percept PC system for ANT-DBS underwent continuous at-home LFP recording of theta/alpha (4-12 Hz) and self-reported seizure logs. Wavelet and Hilbert transforms were used to identify rhythmic cycles in LFPs. Circular statistics quantified seizure phase-locking to LFP cycles and patterns estimated from seizure diaries. Gaussian process regression (GPR) models were trained using the instantaneous phase and amplitude of these cycles to forecast short-term seizure risk.
resultsA total of 7.37 years of at-home LFP recordings were analyzed. All seven participants exhibited circadian and/or multi-day cycles in their ANT LFPs, with seizures significantly phase-locked to some of these cycles. Incorporating the instantaneous cycle amplitude improved seizure forecasting performance across all participants. Moreover, a substantial, although non-significant, positive correlation between circadian cycle power and seizure frequency was found in most participants, suggesting an elevated seizure risk when circadian cycles are stronger. SIGNIFICANCE: This study demonstrates that long-term LFP recordings from the ANT reflect rhythmic brain activity linked to seizure risk, and that cycle amplitude provides complementary information about seizure risk than the phase alone.
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