SynthesisDie Ophthalmologie2026
[Collection of aqueous humor samples for proteome analyses].
Synthesis in Die Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
backgroundIn a single aqueous humor sample, thousands of different proteins can now be detected, providing valuable insights into disease mechanisms of both the anterior and posterior segment of the eye.
objectiveThe aim is to describe the standardized collection of high-quality aqueous humor samples obtained during cataract surgery for proteome analysis. MATERIAL AND
methodsA systematic PubMed literature review was carried out and personal experience of the authors are presented. RESULTS AND
conclusionSampling of aqueous humor has been established in clinical routine for decades, e.g. as diagnostic procedure in uveitis. Cataract surgery is one of the most frequently performed surgeries and thus provides the opportunity to routinely collect aqueous humor samples on alarge scale and without an additional invasive procedure. A standardized process is critical to reproducibly achieve high sample quality. This includes sample collection, immediate snap-freezing on dry ice in the operating room, storage in a biobank and the connection between the sample and clinical data. For proteome analysis, several highly sensitive technologies are available that address the specific challenges of analyzing aqueous humor specimens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.