ArticleJournal of molecular histology2026
Relationship between expression of derived factor-1CXC chemokine receptor 4 in tumor tissues of patients with non-small cell lung cancer and postoperative lymph node metastasis.
Article in Journal of molecular histology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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Who cites it
1 citing paper in PubMed.
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Authors and funding
5 authors.
Funding
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Abstract
The study aims to investigate the correlation between C-X-C Motif Chemokine Receptor 4 (CXCR4) in tumor tissue of non-small cell lung cancer (NSCLC) patients and postoperative lymph node metastasis. The study included 140 individuals diagnosed with NSCLC who had surgery to remove the tumor at the author's hospital between April 2021 and December 2023. All patients were confirmed by histopathological analysis. Imaging methods were used to evaluate whether lymph node metastasis occurred in NSCLC patients after surgery, with 46 cases showing metastasis and 94 cases showing no metastasis. In histopathological analysis, 82 patients had positive expression of C-X-C Motif Chemokine Ligand 12 (CXCL12) and 97 patients had positive expression of CXCR4. Prior to inclusion in the study, each patient provided a signed informed consent form. General patient information data was collected. Immunohistochemical was used to analyze the CXCL12 and CXCR4 in both cancerous and neighboring tissues. The relationship between the expression of CXCL12 and CXCR4 and clinical pathological features such as tumor size and staging, as well as the relationship between the expression of CXCL12 and CXCR4 and postoperative lymph node metastasis, were analyzed. The correlation between CXCL12 and CXCR4 expression in tumor tissues was examined using Spearman correlation analysis. The multiple logistic regression was taken to investigate the factors that influence postoperative lymph node metastasis. The general information of the two groups showed no significant distinction. The CXCL12 and CXCR4 in cancerous tissues were significantly elevated compared to neighboring tissues. The CXCL12 and CXCR4 expression in NSCLC patients did not show any correlation with tumor size, tissue type, or pathological stage. The strong presence of CXCL12 and CXCR4 proteins in patient tumor tissue is closely related to lymph node metastasis. There is a significant positive correlation between CXCL12 and CXCR4 protein levels. Logistic regression analysis indicated that CXCL12 and CXCR4 play a crucial role in postoperative lymph node metastasis, and the elevated expression of these proteins is more associated with lymph node metastasis. The elevated CXCL12 and CXCR4 in tumor tissues are strongly linked to postoperative lymph node metastasis, suggesting that these proteins may be crucial in the NSCLC lymph node metastasis and highlighting their potential as predictors of metastasis risk.
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