Evidence map›Paper›PMID 41697452›Full record

ReviewCurrent oncology reports2026

Integrative Oncology for Biochemical Recurrence of Epithelial Ovarian Cancer.

Tara Berman, Emad Matanes, Chen Ben David, Moshe Frenkel

Abstract readReview
In one paragraph

Review in Current oncology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tara BermanDana-Farber Cancer Institute, 450 Brookline Avenue, Boston, 02115, MA, USA.
Emad MatanesGynecologic Oncology Unit, Department of Obstetrics & Gynecology, Rambam Health Care Campus, Haifa, Israel.
Chen Ben DavidGynecologic Oncology Unit, Department of Obstetrics & Gynecology, Rambam Health Care Campus, Haifa, Israel.
Moshe FrenkelIntegrative Oncology Service, Oncology Division, Rambam Health Care Campus, Hashoftim 1 B, Zichron Yaacov, Haifa, 30900, Israel. frenkelm@netvision.net.il.ORCID 0000-0002-0245-0764

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewBiochemical recurrence of epithelial ovarian cancer (EOC), defined as rising CA-125 levels without clinical or radiologic evidence of disease, is a frequent and challenging scenario. Cytotoxic therapy initiated at this stage does not improve survival and may diminish quality of life. This review evaluates integrative oncology (IO) interventions that may support women during this vulnerable period. RECENT

findingsMind-body therapies, including mindfulness, yoga, and cognitive behavioral therapy, have demonstrated benefits in reducing anxiety, distress, and fear of recurrence. Exercise and acupuncture improve vitality, mood, and sleep. Nutritional strategies-particularly anti-inflammatory diets, vitamin D sufficiency, and omega-3 fatty acid intake-promote resilience and overall health. Natural compounds such as green tea, medicinal mushrooms, modified citrus pectin, melatonin, and AHCC show immune-modulating or anti-tumor effects in preclinical or early clinical studies. Among repurposed non-oncologic drugs, metformin provides the strongest rationale, especially for women with type 2 diabetes. Although ovarian cancer-specific trials are limited, IO approaches are safe, feasible, and evidence-informed. They address psychosocial distress, improve quality of life, and may influence disease biology, offering meaningful options for women under surveillance during biochemical recurrence.

Indexed as

Carcinoma, Ovarian EpithelialIntegrative OncologyNeoplasm Recurrence, LocalNeoplasms, Glandular and EpithelialOvarian NeoplasmsFemaleHumansQuality of LifeBiochemical relapse, epithelial ovarian cancer, complementary medicineCancer careIntegrative oncologyPatient centered careSupportive care

Identifiers

PMID41697452
PMCPMC12909368

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.