Evidence map›Paper›PMID 41697496›Full record

ArticleCardiovascular drugs and therapy2026

Mitochondria at the Heart of Ischemia-Reperfusion (I/R) Injury: the HOXB5-Sirt5 Axis.

Callum J Quinn, Epiphany S Velasco, Xander H T Wehrens

Abstract readEditorial
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In one paragraph

Article in Cardiovascular drugs and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Callum J QuinnCardiovascular Research Institute, Baylor College of Medicine, Houston, TX, 77030, USA.ORCID 0000-0003-1713-5975
Epiphany S VelascoCardiovascular Research Institute, Baylor College of Medicine, Houston, TX, 77030, USA.ORCID 0009-0007-5009-1149
Xander H T WehrensCardiovascular Research Institute, Baylor College of Medicine, Houston, TX, 77030, USA. wehrens@bcm.edu.ORCID 0000-0001-5044-672X

Funding

Junctophilin-2 cleavage in ischemic heart diseaseR01HL153350 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2021 to 2024
$2.3M
NIH HHS R01HL153350
6 · The paper itself

Abstract

Ischemic cardiomyopathy (ICM) arises from restricted myocardial blood flow, leading to ischemia/reperfusion (I/R) injury, mitochondrial dysfunction, and heart failure. This commentary highlights the role of mitochondrial homeostasis in cardiac health, emphasizing dysregulated dynamics, ROS production, and mitophagy in ICM and related conditions like diabetic cardiomyopathy. Li et al.‘s study identifies the HOXB5–Sirt5 signaling axis as a key regulator that protects against I/R injury by reducing apoptosis, oxidative stress, ferroptosis, and mitochondrial fragmentation in vitro and in vivo. Future research should explore cell-specific roles and human models to enhance translational potential.

Indexed as

Homeodomain ProteinsMitochondria, HeartMyocardial Reperfusion InjurySirtuinsAnimalsApoptosisHumansMitophagyOxidative StressSignal TransductionHomeodomain ProteinsSirtuinsFerroptosisI/R injuryIschemic cardiomyopathyMitochondriaMitophagy

Identifiers

PMID41697496

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.