ReviewDiscover nano2026
Coaxial nanofiber design for traumatic brain injury: a review and framework for phase-responsive therapeutics.
Review in Discover nano, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Therapeutic Potential of Oxiracetam in Neurocognitive Disorders: A Narrative Review.Brain and behavior · 2026Review
- Formulation Feasibility of a Mechanically Compliant Stearate Organogel-Methylcellulose/Gelatin Bigel for Localized Neurotherapeutic Delivery.Gels (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traumatic brain injury (TBI) is characterized by an evolving pathophysiology spanning acute, subacute, and chronic stages, each demanding temporally tailored therapeutic interventions. However, conventional drug delivery systems lack the capacity to adapt to these shifting biological windows, limiting therapeutic precision and clinical efficacy. Coaxial electrospun nanofibers, with their spatially distinct core-shell architecture, offer a platform for phase-responsive drug delivery, enabling temporal modulation of therapeutic release. In this review and design framework, we explore how the structural logic of coaxial nanofibers can be leveraged to address the temporally distinct therapeutic needs of TBI. We align polymer composition, fiber geometry, and degradation kinetics with the molecular and cellular hallmarks of each injury phase, emphasizing design strategies that synchronize scaffold behavior with evolving oxidative, neuroinflammatory, and regenerative processes. The review also outlines a roadmap for programmable coaxial electrospun nanofiber design logic for TBI application. By structurally aligning therapeutic delivery with TBI's temporal dynamics, phase-responsive nanofiber scaffolds may advance the field toward more precise, adaptive, and effective neurotherapeutics.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.