ArticleDigestive diseases and sciences2026
A Previous History of Endometriosis Elevates Irritable Bowel Syndrome Risk in Middle-Aged and Older Women: A UK Biobank Cohort Study of 225,703 Participants.
Article in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectiveEndometriosis (EMT) and irritable bowel syndrome (IBS) disproportionately affect middle-aged and older women, where overlapping symptoms (e.g., chronic pelvic pain, bloating) and shared inflammatory mechanisms may drive comorbidity. However, large-scale evidence linking EMT to IBS incidence in this population remains scarce. Leveraging the UK Biobank cohort (N = 225,703), we investigate their longitudinal association to address this critical gap in women's health research.
methodWe sourced data on pre-existing endometriosis (EMT) status and incident IBS diagnoses from the UK Biobank. We employed multivariate Cox regression to analyze the link between baseline EMT and subsequent IBS, as well as the association with different IBS subtypes and severities. Subgroup and sensitivity analyses were also performed.
resultThe study population comprised 225,703 individuals, with 6379 cases (2.83%) exhibiting EMT at initial assessment and 6282 cases (2.78%) developing IBS during a median observation period of 13.8 years (IQR 13-14.5). EMT patients showed significantly elevated cumulative incidence of hypertension compared to population controls (4.61%, p < 0.001). Adjusted Cox models identified EMT as an independent predictor of IBS development (hazard ratio 1.58, 95% CI 1.38-1.82; p < 0.001). Subtype analysis revealed specific risk elevation for constipation-predominant (IBS-C) and mixed-pattern (IBS-M) variants (both p < 0.001), though no significant associations emerged for diarrhea-predominant subtypes(IBS-D). These findings persisted across sensitivity analyses and subgroup evaluations, confirming EMT's robust association with incident IBS.
conclusionClinical data analysis revealed elevated IBS susceptibility among EMT-affected individuals relative to reference populations, with notable predisposition toward IBS-C. These findings suggest clinical relevance of EMT-IBS correlations, requiring integration of EMT status into diagnostic evaluations for gastrointestinal symptom management.
Indexed as
Identifiers
41697512What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.