Evidence map›Paper›PMID 41698162›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2026

Integrin β1 Demarks Precursors of Brain-Residing Antibody-Secreting Cells in Multiple Sclerosis.

Kirsten L Kuiper, Laurens Bogers, Jasper Rip, Yifan van Hasselt, Marie-José Melief, Annet F Wierenga-Wolf, Romy A M Klein Kranenbarg, Eric Bindels, Harmen J G van de Werken, Janet de Beukelaar and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kirsten L KuiperDepartment of Immunology, MS Center ErasMS, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.ORCID 0009-0007-9562-4500
Laurens BogersDepartment of Immunology, MS Center ErasMS, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.ORCID 0000-0002-8490-3076
Jasper RipDepartment of Immunology, MS Center ErasMS, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.ORCID 0000-0001-5780-9271
Yifan van HasseltDepartment of Immunology, MS Center ErasMS, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.ORCID 0000-0002-6541-7435
Marie-José MeliefDepartment of Immunology, MS Center ErasMS, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.ORCID 0000-0003-4625-4260
Annet F Wierenga-WolfDepartment of Immunology, MS Center ErasMS, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Romy A M Klein KranenbargDepartment of Neurology, MS Center ErasMS, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Eric BindelsDepartment of Hematology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.ORCID 0000-0001-9502-669X
Harmen J G van de WerkenDepartment of Immunology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands; and.
Janet de BeukelaarDepartment of Neurology, Albert Schweitzer Hospital, Dordrecht, the Netherlands.ORCID 0009-0000-6089-9896
Ide SmetsDepartment of Neurology, MS Center ErasMS, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.ORCID 0000-0001-8174-2898
Beatrijs WokkeDepartment of Neurology, MS Center ErasMS, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.ORCID 0000-0002-2616-8464
Joost SmoldersDepartment of Immunology, MS Center ErasMS, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.ORCID 0000-0001-9766-8661
Marvin M van LuijnDepartment of Immunology, MS Center ErasMS, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesMultiple sclerosis (MS) is characterized by CXCR3

methodsEx vivo single-cell technologies were applied to blood samples and postmortem CNS suspensions from MS and control donors, either treated or untreated. In addition, in vitro assays were performed on blood samples from healthy individuals to functionally asses B-cell activation, differentiation, and transmigration.

resultsSingle-cell RNA sequencing revealed DISCUSSION: These findings put forward CD29 as a putative marker on CXCR3

Indexed as

Antibody-Producing CellsBrainIntegrin beta1Memory B CellsMultiple SclerosisAdultBiomarkersFemaleHumansMaleReceptors, CXCR3BiomarkersCXCR3 protein, humanIntegrin beta1Itgb1 protein, humanReceptors, CXCR3

Identifiers

PMID41698162
PMCPMC12912196

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.