Observational studyThe Journal of international medical research2026
Association between triglyceride glucose-body mass index and all-cause mortality in patients with sepsis: Evidence from a retrospective cohort study.
Observational study in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BackgroundSepsis remains a leading cause of mortality in critically ill patients, necessitating the identification of reliable prognostic markers. The triglyceride glucose-body mass index, which combines lipid and glucose metabolism, may serve as a valuable predictor of long-term outcomes in this population.MethodsThis study employed a retrospective observational cohort design and analyzed data from the MIMIC-IV database encompassing 2424 septic patients admitted between 2008 and 2019. Patients were categorized into quartiles based on triglyceride glucose-body mass index values. The primary outcomes assessed were all-cause mortality rates at 30, 90, and 180 days as well as 1-year post-admission, and analysis was performed using multivariable Cox proportional hazards models.ResultsIn total, 2424 septic patients meeting the inclusion criteria were finally included in the analyses. Lower triglyceride glucose-body mass index values have been associated with higher long-term mortality outcomes in critically ill septic patients. However, higher triglyceride glucose-body mass index quartiles were associated with a significant reduction in mortality risk at 180 days and 1 year after admission, even after adjustment for potential confounding variables. Patients in the third (hazard ratio: 0.81, 95% confidence interval: 0.67-0.98,
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