Evidence map›Paper›PMID 41698880›Full record

ArticleGut microbes2026

HLA-B27-associated gut microbiota and amino acid perturbations promote ankylosing spondylitis through M1 macrophage activation.

Tianwen Huang, Hang Yang, Lingshu Zhang, Xiangpeng Wang, Ye Chen, Huanzi Dai, Kenji Hashimoto, Yubin Luo, Yaoyu Pu, Yi Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tianwen HuangDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, People's Republic of China.ORCID 0009-0006-0720-7049
Hang YangDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Lingshu ZhangDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Xiangpeng WangDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Ye ChenDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Huanzi DaiDepartment of Rheumatology and Immunology, Daping Hospital, Army Military Medical University, Chongqing, People's Republic of China.
Kenji HashimotoChiba University Center for Forensic Mental Health, Chiba, Japan.ORCID 0000-0002-8892-0439
Yubin LuoDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, People's Republic of China.ORCID 0000-0002-7669-1579
Yaoyu PuDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, People's Republic of China.ORCID 0000-0002-7887-3237
Yi LiuDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, People's Republic of China.ORCID 0000-0002-9258-3594

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ankylosing spondylitis (AS) is strongly associated with the human leukocyte antigen B27 (HLA-B27), yet how this genetic risk factor interacts with the gut microbiome remains unclear. We integrated fecal gut microbiota analysis, untargeted metabolomics, and clinical phenotyping in 88 participants, including HLA-B27-positive patients with AS (

Indexed as

Amino AcidsGastrointestinal MicrobiomeHLA-B27 AntigenMacrophage ActivationMacrophagesSpondylitis, AnkylosingAdultAnimalsBacteriaFecal Microbiota TransplantationFecesFemaleHumansMaleMetabolomicsMiceAmino AcidsHLA-B27 Antigenamino acidsAnkylosing spondylitisgut microbiotaHLA-B27metabolome

Identifiers

PMID41698880
PMCPMC12915779

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.