Trial reportScientific reports2026
Prognostic significance of heart rate trajectories on organ failure in predicted severe acute pancreatitis: secondary analysis of a randomized trial.
Trial report in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elevated heart rate is associated with poor clinical outcomes across various patient populations, including acute pancreatitis. This study aimed to assess whether trajectories of daily highest heart rate during the acute phase were associated with prolonged organ failure in patients with predicted severe acute pancreatitis (pSAP). This was a secondary analysis of data from a multicenter, randomized, controlled trial that assessed the effects of different crystalloids in patients with pSAP. Based on the daily highest heart rate trajectories over the first five days, patients were categorized into two groups: persistent high (PH) and transient high (TH). The primary outcome was the presence of organ failure or death on day 7. The association between different heart rate trajectories and the primary outcome was modeled with selected confounders (age, gender, BMI, etiologies, and the presence of necrosis at admission). The Multivariable Cox regression model was used to evaluate the association between heart rate trajectories and time to alive and full organ failure resolution. Overall, 183 patients were included in the analysis, of whom 41 (22.4%) were categorized in the PH group and 142 (77.6%) in the TH group. The incidence of organ failure or death on day 7 in the PH group was more than twice as high as that in the TH group (56.1% vs. 23.0%; p < 0.001). After adjustment, the results remained significant (odds ratio 3.85; 95% CIs 1.70–8.99; p = 0.001). Compared to the TH group, patients in the PH group also had a lower cumulative probability of alive and full organ failure resolution within 7 days of enrollment (hazard ratio 0.33; 95% CIs 0.14–0.77; log-rank p = 0.004). Persistent elevated heart rate during the acute phase is associated with more prolonged organ failure in patients with pSAP, indicating that early heart rate control may be a potential therapeutic strategy to improve clinical outcomes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.