ArticleJournal of perinatology : official journal of the California Perinatal Association2026
Predicting pulmonary hypertension in infants with bronchopulmonary dysplasia.
Henry P Foote, Minghui Sun, Benjamin Alan Goldstein, Kevin D Hill, Rachel G Greenberg, Samuel J Gentle, Kanecia O Zimmerman, Rishikesan Kamaleswaran, Veeral N Tolia, Matthew M Laughon and 2 more
Abstract read
In one paragraphArticle in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors.
Henry P FooteDepartment of Pediatrics, Duke University Medical Center, Durham, NC, USA.
Benjamin Alan GoldsteinDepartment of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, USA.
Kevin D HillDepartment of Pediatrics, Duke University Medical Center, Durham, NC, USA.
Kanecia O ZimmermanDepartment of Pediatrics, Duke University Medical Center, Durham, NC, USA.
Rishikesan KamaleswaranDepartment of Surgery, Duke University Medical Center, Durham, NC, USA.
Veeral N ToliaPediatrix Center for Research, Quality, Education and Safety, Sunrise, FL, USA.
Funding
Safety of Sildenafil in Premature Infants with Severe Bronchopulmonary DysplasiaR33HL147833 · NHLBI · DUKE UNIVERSITY · PI HORNIK, CHRISTOPH, LAUGHON, MATTHEW · 2021 to 2023
$6.8MUnified Program for Therapeutics in Children (UPTiC)T32HD094671 · NICHD · DUKE UNIVERSITY · PI Ian J Davis, Kanecia Obie Zimmerman · 2019 to 2026
$2.9MSepsis Physiomarkers for Appropriate Risk Knowledge of monitored patients in the ICU (SPARK-ICU)R01GM139967 · NIGMS · EMORY UNIVERSITY · PI KAMALESWARAN, RISHIKESAN · 2021 to 2025
$2.8MDuke-UNC Collaborative Pediatric Clinical Pharmacology Postdoctoral Training ProgramT32HD104576 · NICHD · DUKE UNIVERSITY · PI BROUWER, KIM L.R., GONZALEZ, DANIEL · 2021 to 2025
$962kDose Optimization for Novel Drugs for Infants with Hypoxic-Ischemic EncephalopathyK23HD111623 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Wesley M Jackson · 2023 to 2026
$690kTherapeutic Strategies for the Management of Bronchopulmonary Dysplasia-Associated Pulmonary HypertensionK23HD113837 · NICHD · YALE UNIVERSITY · PI Samuel J Gentle · 2024 to 2026
$497kMentoring in Pediatric Cardiovascular Pharmacology and Early Phase TrialsK24HL173596 · NHLBI · DUKE UNIVERSITY · PI Christoph Hornik · 2024 to 2026
$363kNHLBI NIH HHS K24 HL173596NHLBI NIH HHS R33 HL147833NICHD NIH HHS K23 HD111623NICHD NIH HHS K23 HD113837NICHD NIH HHS T32 HD094671NICHD NIH HHS T32 HD104576NIGMS NIH HHS R01 GM139967U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 1T32HD104576U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) T32HD094671U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) 1K24HL173596U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) 5R33HL147833
6 · The paper itselfAbstract
objectiveDevelop and validate predictive models for pulmonary hypertension (PH) in high-risk infants. STUDY
designWe trained logistic regression (LR) and long short-term memory (LSTM) models using a multicenter cohort study of infants 22-28 weeks gestational age discharged from neonatal intensive care units from 2008 to 2020, at two timepoints: 33 weeks post-menstrual age (PMA) for infants receiving mechanical ventilation at that time, and 36 weeks PMA for infants receiving any respiratory support at that time.
resultsAt 33 weeks PMA (N = 2849), top LR model predictors were current fraction of inspired oxygen and birth weight. At 36 weeks (N = 20,173), top LR model predictors were current respiratory support and birth weight. Both LR and LSTM models had strong performance in the temporal validation cohort (infants discharged 2021-2022) for both timepoints.
conclusionUsing available clinical variables, we developed and validated predictive models that may identify infants most at risk for PH at two timepoints.
Identifiers
PMID41699091
PMCPMC12991431
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