ArticleCommunications biology2026
Single-nucleus RNA sequencing and functional studies of acute methamphetamine-induced cognitive impairment.
Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The effects of abused drugs on ferroptosis pathways: potential therapeutic targets for substance use disorders.Frontiers in cellular neuroscience · 2026Review
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methamphetamine (Meth) abuse leads to cognitive impairment, with the hippocampus being severely affected. However, the precise cellular mechanisms underlying Meth-induced hippocampal damage remain unclear. This study utilizes single-nucleus RNA sequencing (snRNA-seq) to investigate the transcriptional changes in mouse hippocampal neurons after acute Meth exposure. We analyze 36,376 nuclei isolated from the hippocampus of acute Meth-treated and control mice, revealing significant alterations in excitatory neuron transcriptomes. Notably, oxidative phosphorylation (OXPHOS) and peroxisome pathways were prominently activated. Five distinct excitatory neuron subtypes were identified across different hippocampal regions, with the dorsal-ventral (DG) region exhibiting the most pronounced changes in gene expression, inflammatory response, reactive oxygen species (ROS) signaling, and OXPHOS activity. High-dimensional weighted correlation network analysis (hdWGCNA) reveals five modules endowed with functional roles in recognizing-associated pathways. Furthermore, it provides insights into intercellular communication and transcriptional regulation patterns within the hippocampus after Meth exposure. In conclusion, this study offers a comprehensive understanding of Meth's impact on hippocampal transcriptomes and may guide the development of therapeutic strategies for acute Meth-induced neurotoxicity.
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