ArticleDiscover oncology2026
A bibliometric analysis of research trends and emerging frontiers in heat shock proteins and hepatocellular carcinoma from 2015 to 2025.
Article in Discover oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundHeat shock proteins (HSPs) are key regulators in the pathogenesis, diagnosis, and treatment of Hepatocellular Carcinoma (HCC), but a comprehensive bibliometric analysis covering the latest research progress is lacking. This study aims to systematically depict the research landscape, collaboration network, and emerging trends of HSPs in HCC from 2015 to September 2025.
methodsBased on 817 publications retrieved from the Web of Science Core Collection (WoSCC), a bibliometric analysis was conducted using CiteSpace, VOSviewer, and Bibliometrix R tools.
resultsThe annual publication output in this field showed fluctuating growth, with the cumulative scale continuously expanding and academic attention steadily increasing. China was the largest contributor with 503 papers (accounting for 59.32%), whereas the United States played a central role in international collaboration and demonstrated high academic influence (average 33.69 citations per paper, total link strength 74). Institutional analysis revealed that Chinese institutions, including Zhejiang University and Fudan University, formed close domestic collaboration networks, with Fudan University ranking first in influence (average 33.30 citations per paper). Keyword analysis indicated that research themes are evolving from classical mechanisms such as “apoptosis” and “oxidative stress” toward emerging directions, including “network pharmacology” (with the highest burst strength), “tumor microenvironment (TME)”, and “nanoparticles”. Highly cited publications were predominantly reviews (70%), focusing on mechanisms such as ferroptosis, suggesting the field is experiencing a phase of knowledge synthesis alongside active original investigation.
conclusionThis study comprehensively reveals the development characteristics of the field, providing crucial insights for scholars to understand research trends, plan frontier directions, and promote translational research.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.