ArticleBMC infectious diseases2026
Epidemiological, clinical and laboratorial features of rotavirus infection in older children and adults: a multicenter hospital-based study in east China.
Article in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundRotavirus (RV) is a leading cause of infectious gastroenteritis and associated deaths worldwide, imposing a substantial disease burden in China. This study aimed to describe the epidemiological characteristics, clinical manifestations and dominant genotypes of rotavirus infection in Zhejiang Province and evaluated risk factors for severe RV-associated diarrhea.
methodsA prospective study was conducted on patients with acute gastroenteritis (AGE) from multicenter hospitals in Zhejiang Province between 2023 and 2024. Relevant information was collected through epidemiological questionnaires and electronic medical records. Fecal samples were collected to detect pathogens and G/P serotypes.
resultsA total of 4,810 RV-infected patients were enrolled, including 75.95% aged 0–59 months, 22.56% aged 5–14 years, 0.95% aged 15–64 years and 0.54% aged ≥ 65 years. The gender distribution showed a slight male predominance. Regionally, Hangzhou had the highest number of cases (60.35%), while seasonally, spring was the peak period (65.09%), followed by winter (22.41%). Epidemiologically, the 5–14 years group had the highest per capita gross domestic product (GDP) in their residential areas, while the ≥ 65 years group had the highest average air temperature and the lowest relative humidity (P<0.05). Among the 130 RV-positive patients selected for clinical characteristics and genotype analysis (accounting for 2.70% of the total 4,810 cases), diarrhea (93.08%), vomiting (62.31%), and fever (12.31%) were the primary clinical manifestations. The average duration of diarrhea was 2.10 days (95% CI: 1.70-2.58) with 5.05 episodes per 24 hours, and the average duration of vomiting was 0.99 days (95% CI: 0.79-1.19) with 2.90 episodes per 24 hours. As for vaccination status, 78.46% of the 130 patients were unvaccinated, while 12.31% received pentavalent RV vaccine and 9.23% received domestic RV vaccine. The dominant genotypes were G8P[8] (32.31%) and G9P[8] (27.69%), with consistent genotype distribution patterns across different age groups (P>0.05). Regarding the severe rotavirus diarrhea analysis, 39.23% had severe diarrhea and 60.77% had non-severe diarrhea. Severe cases were characterized by longer durations of diarrhea and vomiting, higher frequencies of diarrhea and vomiting within 24 hours, and a higher proportion of high fever compared to non-severe cases (P<0.05). Genotype distribution also differed significantly between the two groups (P<0.05), with G3P[8] accounting for a much higher proportion in severe cases (17.56%) than in non-severe cases (1.27%). Multivariate logistic regression analysis showed that genotype G3P[8] (OR=21.67, 95% CI: 2.90-470.89) and delayed admission (1-3 days: OR=5.89, ≥ 3 days: OR=6.46) were independent risk factors for severe RV-associated diarrhea (P<0.05).
conclusionThis study clarifies the epidemiological, genotypic and clinical characteristics of RV infection in Zhejiang Province, providing a basis for precise prevention and control of RV infection and intervention for severe RV-associated diarrhea.
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