Evidence map›Paper›PMID 41699864›Full record

ArticleBrain and behavior2026

Unveiling Shared Genetic Architectures and Causality: Intestinal Diseases and Neurological Diseases.

Ning Zhao, Shiheng Tan, Qingzhen Fu, Yanbing Li, Tian Tian, Zesong Cheng, Ding Zhang, Lijing Gao, Weiwei Bao, Depei Zhang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ning ZhaoDepartment of Epidemiology, School of Public Health, Harbin Medical University, Harbin, P.R. China.
Shiheng TanDepartment of Epidemiology, School of Public Health, Harbin Medical University, Harbin, P.R. China.
Qingzhen FuDepartment of Epidemiology, School of Public Health, Harbin Medical University, Harbin, P.R. China.
Yanbing LiDepartment of Epidemiology, School of Public Health, Harbin Medical University, Harbin, P.R. China.
Tian TianDepartment of Epidemiology, School of Public Health, Harbin Medical University, Harbin, P.R. China.
Zesong ChengDepartment of Epidemiology, School of Public Health, Harbin Medical University, Harbin, P.R. China.
Ding ZhangDepartment of Epidemiology, School of Public Health, Harbin Medical University, Harbin, P.R. China.
Lijing GaoDepartment of Epidemiology, School of Public Health, Harbin Medical University, Harbin, P.R. China.
Weiwei BaoDepartment of Epidemiology, School of Public Health, Harbin Medical University, Harbin, P.R. China.
Depei ZhangDepartment of Epidemiology, School of Public Health, Harbin Medical University, Harbin, P.R. China.
Zinan LiDepartment of Epidemiology, School of Public Health, Harbin Medical University, Harbin, P.R. China.
Jinyin LiuDepartment of Epidemiology, School of Public Health, Harbin Medical University, Harbin, P.R. China.
Liwan WangDepartment of Epidemiology, School of Public Health, Harbin Medical University, Harbin, P.R. China.
Zhuobo ZhangDepartment of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, P.R. China.ORCID https://orcid.org/0000-0003-1845-9285
Fan WangDepartment of Epidemiology, School of Public Health, Harbin Medical University, Harbin, P.R. China.ORCID https://orcid.org/0000-0002-9869-9504
Yashuang ZhaoDepartment of Epidemiology, School of Public Health, Harbin Medical University, Harbin, P.R. China.ORCID https://orcid.org/0000-0002-7425-5773

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe "gut-brain axis" provides a theoretical foundation for the connection between intestinal and neurological diseases, but whether this reflects a shared genetic etiology or causal relationships exist remains unclear.

methodsWe used genome-wide association study summary data from FinnGen and UK Biobank to investigate the genetic correlations and causal relationships between three intestinal diseases and six neurological diseases.

resultsWe observed positive global genetic correlations between irritable bowel syndrome and epilepsy (r

conclusionsThrough comprehensive and systematic statistical analysis, we identified the global and local genetic correlations and causal relationships between several intestinal and neurological diseases and discovered shared pleiotropic loci and genes between them. Furthermore, the consistent SNP heritability enrichment observed in immune cells also indicated the crucial role of the immune system in the "gut-brain axis."

Indexed as

EpilepsyIntestinal DiseasesIrritable Bowel SyndromeMultiple SclerosisNervous System DiseasesColitis, UlcerativeCrohn DiseaseGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMendelian Randomization AnalysisParkinson DiseasePolymorphism, Single NucleotideStrokegenetic association"gut–brain axis," immune systemGWAS

Identifiers

PMID41699864
PMCPMC12910125

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.