ArticleTranslational vision science & technology2026
Clinical and Molecular Characteristics of Foveal Sparing Phenotype in Chinese Patients With Inherited Retinal Diseases.
Article in Translational vision science & technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The purpose of this study was to evaluate the clinical characteristics of the foveal sparing phenotype among patients with inherited retinal diseases (IRDs) and to identify the predictive imaging markers for visual prognosis. Methods: Consecutive patients with definitive clinical and genetic diagnoses of IRD who first visited our clinic from November 2021 to December 2022 and had high-quality spectral-domain optical coherence tomography (SD-OCT) images were included in this retrospective cohort. The foveal sparing phenotype was defined by foveal preservation on autofluorescence (FAF) and OCT images. Best-corrected visual acuity (BCVA) and dimensions of residual structures of outer retinal layers on OCT and FAF images were measured and analyzed. Spearman correlation analysis was performed to evaluate the correlation between retinal imaging features and BCVA. Receiver operating characteristic (ROC) curve was performed to assess the predictive performance of residual ellipsoid zone (EZ) area on OCT. Results: A total of 601 eyes of 308 Chinese patients with IRD were enrolled. Foveal sparing phenotype was observed in 195 (32.4%) eyes of 105 (34.1%) patients. There were 46.7% of cases with USH2A-related retinopathy and 76.9% EYS-related retinopathy presented foveal sparing phenotype, whereas their structural integrity showed no significant difference. Spearman correlation analyses revealed significant association between residual EZ area (P < 0.01) and BCVA. ROC curve analysis demonstrated that the residual EZ area at initial diagnosis could predict the degree of BCVA deterioration within 2 years (area under the curve [AUC] = 0.70). Conclusions: Our findings indicate that the foveal sparing phenotype is associated with better visual prognosis and is more frequently observed in IRDs associated with EYS and USH2A mutations. The residual EZ area on OCT can serve as a predictor of the timeframe for central vision deterioration to blindness in patients with IRD. Translational Relevance: Residual EZ area on OCT can serve as a predictive biomarker to support clinical decision making in monitoring and managing the progression of IRD.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.