Evidence map›Paper›PMID 41700807›Full record

ArticleEpilepsia open2026

Automated analysis of postictal generalized electroencephalogram suppression for SUDEP risk stratification.

Steve D Reddy, Suprith Balasubramanian, Sreevidhya Ramakrishnan, Doodipala Samba Reddy

Abstract read
In one paragraph

Article in Epilepsia open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Steve D ReddyDepartment of Neuroscience and Experimental Therapeutics, Vashisht College of Medicine, Texas A&M University Health Science Center, Bryan, Texas, USA.
Suprith BalasubramanianDepartment of Neuroscience and Experimental Therapeutics, Vashisht College of Medicine, Texas A&M University Health Science Center, Bryan, Texas, USA.
Sreevidhya RamakrishnanDepartment of Neuroscience and Experimental Therapeutics, Vashisht College of Medicine, Texas A&M University Health Science Center, Bryan, Texas, USA.
Doodipala Samba ReddyDepartment of Neuroscience and Experimental Therapeutics, Vashisht College of Medicine, Texas A&M University Health Science Center, Bryan, Texas, USA.ORCID https://orcid.org/0000-0003-2735-9550

Funding

Novel pediatric anticonvulsants for nerve agentsU01NS117209 · NINDS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI REDDY, DOODIPALA SAMBA · 2020 to 2024
$3.7M
Novel Anticonvulsants for Nerve Agents and Refractory Status EpilepticusUG3NS138911 · NINDS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI Doodipala Samba Reddy · 2025 to 2026
$1.1M
NIH HHS U01NS117209NIH HHS UG3NS138911NINDS NIH HHS U01 NS117209NINDS NIH HHS UG3 NS138911U.S. Department of Defense HT94252410174U.S. Department of Defense HT94252510237U.S. Department of Defense W81XWH2210275
6 · The paper itself

Abstract

Sudden unexpected death in epilepsy (SUDEP) affects more than 3000 individuals annually, yet objective and scalable biomarkers to assess risk remain limited. Postictal generalized electroencephalogram suppression (PGES) has been proposed as a potential biomarker, but its quantification is often subjective and variable. Here, we developed and validated an automated Cumulative Sum (CuSUM)-based algorithm to objectively quantify PGES duration in traumatic brain injury (TBI) mouse models of epilepsy. The algorithm was tested across three cohorts:

Indexed as

Brain Injuries, TraumaticElectroencephalographyEpilepsySudden Unexpected Death in EpilepsyAlgorithmsAnimalsDisease Models, AnimalHistone Deacetylase InhibitorsMaleMiceMice, Inbred C57BLRisk AssessmentVorinostatHistone Deacetylase InhibitorsVorinostatbrain injuryepilepsypostictal suppressionseizureSUDEP

Identifiers

PMID41700807
PMCPMC13052317

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.