ArticleInflammopharmacology2026
Methanol extract of Chenopodium murale L. attenuated TNF-α-mediated oxidative stress and inflammation in murine models.
Article in Inflammopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Herbal remedies have been utilised in traditional medicine systems to manage chronic illnesses. The present research investigated the antioxidant, anti-inflammatory, and antiarthritic effects of Chenopodium murale L. The C. murale (CMMeE) methanolic extract, prepared from the whole plant by maceration, was analysed for phytochemicals using LC-MS. The antioxidant effects of CMMeE were assessed in an in vitro DPPH assay. The efficacy of CMMeE was assessed in in vivo carrageenan and histamine-induced acute inflammatory models, and in formaldehyde and complete Freund's adjuvant (CFA)-induced chronic arthritis models. Three different doses of CMMeE (250, 500, and 750 mg/kg) and 10 mg/kg of diclofenac sodium were administered orally to the animals. Different parameters, including reductions in paw oedema, arthritic index (AI), histopathological, biochemical, and haematological changes, were noted. ELISA and qPCR methods were used to assess the expression of antioxidant and inflammatory biomarkers in serum samples. CMMeE possesses moderate antioxidant activity (IC
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