ArticleEuropean stroke journal2026
Arterial ischaemic stroke in adolescents and very young adults-results of a European cohort.
Article in European stroke journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionArterial ischaemic stroke (AIS) in adolescents and young adults differs from older populations due to its variety of risk factors and aetiologies. This study compares the risk factor profiles and age- and sex-related differences between adolescents and very young adults. PATIENTS AND
methodsPooled data from three multicentre cohort studies in Europe (Germany, France, The Netherlands) were analysed. First-ever symptomatic AIS cases in adolescents (10-18 years) and very young adults (18-30 years) were classified using both a paediatric AIS classification (multiple risk factor category system) and the modified Trial of ORG 10172 in Acute Stroke Treatment criteria for adults.
resultsThe cohort includes 142 adolescents (median age 15) and 131 very young adults (median age 25). Using the adult AIS classification, cryptogenic stroke was most common (43% in adolescents, 32% in young adults). Thirty-two percent had other determined aetiologies. The paediatric classification showed similar results regarding identified causes; 29% resulted in cryptogenic stroke, respectively. Sex distribution differed by age: male predominance in adolescents (61%) and female predominance in young adults (57%). DISCUSSION: Adolescence and young adulthood may represent a shared age group with similar causes and risk profiles for AIS. The high rate of cryptogenic stroke suggests potential limitations in current classification systems for AIS aetiology at these ages.
conclusionThis cohort highlights the need for an age-adapted risk factor system that accounts for the transitional nature and the complexity of stroke in this age group.
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