Evidence map›Paper›PMID 41701821›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Up-regulation of Minibrain/DYRK1A contributes to macrocephaly and brain overgrowth in a

Mark Colt, Alicia Gordon, Yi-Jheng Peng, Ying Wu, Katherine Martin, Karen T Chang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mark ColtZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.
Alicia GordonZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.
Yi-Jheng PengZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.ORCID 0009-0007-2344-8990
Ying WuZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.ORCID 0009-0008-4064-9492
Katherine MartinZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.
Karen T ChangZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.ORCID 0000-0001-7619-8170

Funding

Role of DYRK1A/MNB in Synaptic growth and functionR01NS080946 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KAREN T CHANG · 2013 to 2026
$5.0M
Molecular mechanisms underlying activity-induced synaptic remodelingR01NS102260 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHANG, KAREN T · 2018 to 2022
$2.2M
HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS080946HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS102260NINDS NIH HHS R01 NS080946NINDS NIH HHS R01 NS102260
6 · The paper itself

Abstract

Fragile X syndrome (FXS) is the leading cause of inherited intellectual disability and autism. One common physical feature of FXS is macrocephaly, a condition typically associated with brain overgrowth and dysfunction; however, the mechanisms underlying its occurrence are unclear. Here, we uncover a role for the fragile X messenger ribonucleoprotein (FMRP) in regulating tissue growth through the Minibrain (Mnb) kinase, also known as DYRK1A, a gene up-regulated in Down syndrome and mutated in a specific form of autism. Using fly models of FXS, we find that

Indexed as

BrainDrosophila ProteinsFragile X SyndromeMegalencephalyProtein Serine-Threonine KinasesProtein-Tyrosine KinasesAnimalsDisease Models, AnimalDrosophila melanogasterDyrk KinasesFragile X Messenger Ribonucleoprotein 1Signal TransductionUp-RegulationDrosophila ProteinsDyrk KinasesFMR1 protein, DrosophilaFragile X Messenger Ribonucleoprotein 1mnb protein, DrosophilaProtein Serine-Threonine KinasesProtein-Tyrosine Kinasesbrain overgrowthDrosophilafragile X syndromemacrocephalyMinibrain

Identifiers

PMID41701821
PMCPMC12933052

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.