Evidence map›Paper›PMID 41702882›Full record

ArticleTranslational psychiatry2026

Genome-wide association study of social isolation in 63,497 Japanese individuals from the general population.

Hisashi Ohseto, Kosuke Inoue, Ippei Takahashi, Taku Obara, Akira Narita, Mami Ishikuro, Masatsugu Orui, Keiko Murakami, Aoi Noda, Genki Shinoda and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Hisashi OhsetoInternational Research Institute of Disaster Science, Tohoku University, Sendai, Japan.ORCID http://orcid.org/0000-0001-6716-9095
Kosuke InoueDepartment of Health Promotion and Behavioral Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Ippei TakahashiGraduate School of Medicine, Tohoku University, Sendai, Japan.
Taku ObaraGraduate School of Medicine, Tohoku University, Sendai, Japan.
Akira NaritaGraduate School of Medicine, Tohoku University, Sendai, Japan.
Mami IshikuroGraduate School of Medicine, Tohoku University, Sendai, Japan.
Masatsugu OruiInternational Research Institute of Disaster Science, Tohoku University, Sendai, Japan.
Keiko MurakamiTohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Aoi NodaGraduate School of Medicine, Tohoku University, Sendai, Japan.
Genki ShinodaGraduate School of Medicine, Tohoku University, Sendai, Japan.
Masato TakaseGraduate School of Medicine, Tohoku University, Sendai, Japan.
Naoki NakayaGraduate School of Medicine, Tohoku University, Sendai, Japan.
Mana KogureGraduate School of Medicine, Tohoku University, Sendai, Japan.
Rieko HatanakaGraduate School of Medicine, Tohoku University, Sendai, Japan.
Kumi NakayaGraduate School of Medicine, Tohoku University, Sendai, Japan.
Ippei ChibaGraduate School of Medicine, Tohoku University, Sendai, Japan.
Sayuri TokiokaGraduate School of Medicine, Tohoku University, Sendai, Japan.
Yuka KotozakiDepartment of Hygiene and Preventive Medicine, Iwate Medical University, Iwate, Japan.ORCID http://orcid.org/0000-0002-4659-1200
Atsushi ShimizuIwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan.
Kozo TannoDepartment of Hygiene and Preventive Medicine, Iwate Medical University, Iwate, Japan.
Atsushi HozawaGraduate School of Medicine, Tohoku University, Sendai, Japan.
Gen TamiyaGraduate School of Medicine, Tohoku University, Sendai, Japan.
Naoki KondoDepartment of Social Epidemiology, Graduate School of Medicine and School of Public Health, Kyoto University, Kyoto, Japan.
Shinichi KuriyamaInternational Research Institute of Disaster Science, Tohoku University, Sendai, Japan. shinichi.kuriyama.e6@tohoku.ac.jp.ORCID http://orcid.org/0000-0002-6445-0911

Funding

Japan Agency for Medical Research and Development (AMED) JP17km0105001, JP21tm0124005, and JP21tm0424601Ministry of Education, Culture, Sports, Science and Technology (MEXT) 19H03894 and 22H03346
6 · The paper itself

Abstract

Social isolation, characterized by a lack of social connections with family, friends, and others, is associated with adverse health outcomes. However, the genetic contribution to the susceptibility to social isolation remains unclear. This study aimed to identify genetic loci associated with social isolation using the Lubben Social Network Scale (LSNS-6) in a Japanese population. The Tohoku Medical Megabank Community-Based Cohort Study was conducted between 2013 and 2016. The participants were genotyped using the Affymetrix Axiom Japonica Array. The LSNS-6 was used to assess familial and friend ties through six questions and social isolation statuses were defined using the total scale, family subscale, and friend subscale. Genome-wide association studies (GWASs) were conducted using a generalized linear mixed model, adjusting for age, sex, 10 genetic principal components and batch effects. In total, 63,497 participants who completed genotyping and the LSNS-6 were included. The mean age was 59.4 ± 11.9 years, and 41,126 (64.8%) were female. Significant genetic loci were identified in GWASs for the total scale (rs10736933 near ACADSB and HMX3) and friend subscale of LSNS-6 (rs1778366 near LINC02315 and LRFN5). This study provides the first genome-wide evidence of social isolation in the Japanese population, suggesting associations with ACADSB, HMX3, LINC02315, and LRFN5. These findings could enable personalized prevention and intervention for social isolation and related psychiatric disorders.

Indexed as

Social IsolationAgedCohort StudiesEast Asian PeopleFemaleGenetic LociGenome-Wide Association StudyGenotypeHumansJapanMaleMiddle AgedPolymorphism, Single Nucleotide

Identifiers

PMID41702882
PMCPMC13004915

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.