Evidence map›Paper›PMID 41703263›Full record

ArticleJournal of cellular and molecular medicine2026

Systematic Identification and Functional Validation of CASP10 as a DNA-Damage-Responsive Driver of Endothelial Pyroptosis in Atherosclerosis.

Xiangrong Meng, Kejian Zhang, Yu Xi, Zhuozhong Wang, Xinyu Zhu, Wenjing Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. PeerJ · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiangrong MengDepartment of Laboratory Diagnosis, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Kejian ZhangDepartment of Orthopedic Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Yu XiDepartment of Laboratory Diagnosis, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Zhuozhong WangThe Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Harbin, Heilongjiang, China.
Xinyu ZhuCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang, China.
Wenjing ZhangDepartment of Laboratory Diagnosis, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.ORCID https://orcid.org/0000-0002-4507-5351

Funding

Fundamental Research Funds for the Provincial Universities 2017LCZX67National Natural Science Foundation of China 82001715National Natural Science Foundation of China 82204147Research Project of the Health and Family Planning Commission of Heilongjiang Provincial 2018286
6 · The paper itself

Abstract

Atherosclerosis (AS) is a chronic inflammatory disease driven by endothelial dysfunction and plaque instability. The DNA damage response (DDR) has been implicated in endothelial cell fate; its precise role in AS remains unclear. This study aims to identify DDR-related biomarkers associated with AS and elucidate their mechanisms in endothelial pyroptosis. Our analysis identified 66 DDR-related genes, which achieved over 80% accuracy in discriminating early from advanced lesions and hemorrhagic from non-hemorrhagic plaques in external datasets, and reached 100% accuracy in differentiating plaque stability. CASP10 emerged as a top diagnostic biomarker (AUC = 0.991) compared to other DDR genes. Single-cell analysis confirmed elevated CASP10 expression in endothelial cells of AS plaques. Functional experiments revealed that CASP10 is both necessary and sufficient for ox-LDL-induced DNA damage and pyroptosis in HUVECs. CASP10 overexpression exacerbated γH

Indexed as

AtherosclerosisDNA DamagePyroptosisBiomarkersEndothelial CellsHistonesHumansHuman Umbilical Vein Endothelial CellsLipoproteins, LDLNLR Family, Pyrin Domain-Containing 3 ProteinPlaque, AtheroscleroticBiomarkersHistonesLipoproteins, LDLNLR Family, Pyrin Domain-Containing 3 Proteinoxidized low density lipoprotein

Identifiers

PMID41703263
PMCPMC12912935

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.