Evidence map›Paper›PMID 41703635›Full record

ReviewCancer imaging : the official publication of the International Cancer Imaging Society2026

Cancer predisposition syndromes: an imaging review.

Livja Mertiri, Huy Brandon Tran, Denada Mertiri, Maarten Lequin, Nilesh K Desai, Thierry A G M Huisman

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer imaging : the official publication of the International Cancer Imaging Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Livja MertiriEdward B. Singleton Department of Radiology, Texas Children's Hospital, Baylor College of Medicine, 6701 Fannin Street, Suite 470, Houston, TX, 77030 , USA. lxmertir@texaschildrens.org.
Huy Brandon TranEdward B. Singleton Department of Radiology, Texas Children's Hospital, Baylor College of Medicine, 6701 Fannin Street, Suite 470, Houston, TX, 77030 , USA.
Denada MertiriFaculty of Medicine and Surgery, Università di Tor Vergata, Rome, Italy.
Maarten LequinEdward B. Singleton Department of Radiology, Texas Children's Hospital, Baylor College of Medicine, 6701 Fannin Street, Suite 470, Houston, TX, 77030 , USA.
Nilesh K DesaiEdward B. Singleton Department of Radiology, Texas Children's Hospital, Baylor College of Medicine, 6701 Fannin Street, Suite 470, Houston, TX, 77030 , USA.
Thierry A G M HuismanEdward B. Singleton Department of Radiology, Texas Children's Hospital, Baylor College of Medicine, 6701 Fannin Street, Suite 470, Houston, TX, 77030 , USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCancer predisposition syndromes (CPSs) are inherited disorders that increase the risk of developing cancer from childhood through adulthood. They account for up to 10% of pediatric tumors, making early recognition important for reducing morbidity and mortality. Because these syndromes show variable penetrance and a wide range of clinical presentations even within the same family, identifying affected children can be challenging. MAIN BODY: Imaging is an essential tool for diagnosis, surveillance and follow-up of children with cancer predisposition syndromes. In this review we summarize the main clinical and imaging features of Neurofibromatosis type 1, Neurofibromatosis type 2, von Hippel–Lindau disease, PTEN-hamartoma tumor syndrome, Beckwith–Wiedemann syndrome, and multiple endocrine neoplasia. The goal is to help radiologists and clinicians identify these conditions earlier and improve patient care.

conclusionA clear understanding of the clinical and imaging features of cancer predisposition syndromes can support earlier identification, closer surveillance, and improved outcomes. Radiologists play a crucial role in recognizing characteristic patterns and guiding timely management for affected children and their families.

Indexed as

Diagnostic ImagingNeoplastic Syndromes, HereditaryBeckwith-Wiedemann SyndromeChildGenetic Predisposition to DiseaseHamartoma Syndrome, MultipleHumansMultiple Endocrine NeoplasiaNeurofibromatosis 1Neurofibromatosis 2von Hippel-Lindau DiseaseBeckwith-Wiedemann syndromeCancer predisposition syndromesMultiple endocrine neoplasiaNeurofibromatosis type 1Neurofibromatosis type 2PTEN - hamartoma tumor syndromeVon Hippel-Lindau disease

Identifiers

PMID41703635
PMCPMC13015055

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.