ArticleCancer biology & medicine2026
Expert consensus on the detection and clinical application of tumor mutational burden.
Abstract readConsensus Statement
In one paragraph
Article in Cancer biology & medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2citing papers in PubMed
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171 authors.
Zhenying Guo *Cancer Center, Department of Pathology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310014, China.
Chunwei Xu *Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China.
Shirong Zhang *Translational Medicine Research Center, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Cancer Center, Westlake University School of Medicine, Hangzhou 310006, China.
Yue Hao *Department of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou 310022, China.
Xiaotong HuDepartment of Pathology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China.
Ming ZhaoNingbo Clinical Pathology Diagnosis Center, Ningbo 315100, China.
Chan XiangDepartment of Pathology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China.
Yingshi PiaoDepartment of Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Pingli SunDepartment of Pathology, The Second Hospital of Jilin University, Changchun 130041, China.
Xueping XiangDepartment of Pathology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Jing ZhaoDepartment of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
Huanwen WuDepartment of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China.
Weixing LiLaboratory Medicine Center, Zhejiang Center for Clinical Laboratory, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou 310014, China.
Jinpu YuDepartment of Cancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
Jingping YuanDepartment of Pathology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Shuangshuang WangDepartment of Pathology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, China.
Cong WangDepartment of Pathology, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), Nanjing 210029, China.
Yun GuDepartment of Pathology, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing 210004, China.
Bingjian LvDepartment of Surgical Pathology Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, of China.
Liping ZhangDepartment of Pathology, Shanghai Pudong Hospital, School of Medicine, Fudan University, Shanghai 201399, China.
Yueping LiuDepartment of Pathology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.
Xiaobin CuiDepartment of Pathology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China.
Weizhong GuDepartment of Pathology, Children's Hospital Zhejiang University School of Medicine, Hangzhou 310005, China.
Yining LiDepartment of Pathology, Stomatology Hospital, School of Stomatology, Zhejiang University, Hangzhou 310000, China.
Wei WangDepartment of Pathology, Tongde Hospital of Zhejiang Province, Hangzhou 310012, China.
Wenjun YangDepartment of Pathology, Affiliated Hospital of Hangzhou Normal University, Hangzhou 310000, China.
Weiguo LongDepartment of Pathology, The People's Hospital of Leshan, Leshan 614000, China.
Jingjing XiangDepartment of Pathology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou 310006, China.
Hong MouDepartment of Pathology, Chun'an First People's Hospital, Hangzhou 311700, China.
Biao LiuDepartment of Pathology, The Affiliated Suzhou Hospital, Nanjing Medical University, Suzhou 215006, China.
Huajuan RuanDepartment of Pathology, The First People's Hospital of Hangzhou Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou 311300, China.
Yubin WangDepartment of Pathology, Tiantai County People's Hospital, Taizhou 317200, China.
Yongjie ZhuDepartment of Pathology, First People's Hospital of Aksu, Aksu 843000, China.
Feng WangDepartment of Pathology, Xianju People's Hospital, Zhejiang Southeast Campus of Zhejiang Provincial People's Hospital, Affiliated Xianju's Hospital, Hangzhou Medical College, Taizhou 317300, China.
Zhonghua WangDepartment of Pathology, Dinghai Branch of Zhejiang Provincial People's Hospital, Zhoushan 316000, China.
Xiaomin FengDepartment of Pathology, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing 210004, China.
Xing LiuDepartment of Pathology, Shulan (Hangzhou) Hospital, Hangzhou 310022, China.
Peng LiDepartment of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Min DengDepartment of Pathology, Zhejiang Provincial People's Hospital (Fuyang Campus), Hangzhou 311400, China.
Bin LianKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Melanoma and Sarcoma, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Lili MaoKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Melanoma and Sarcoma, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Qian WangDepartment of Respiratory Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, China.
Wenxian WangDepartment of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou 310022, China.
Zhengbo SongDepartment of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou 310022, China.
Ziming LiDepartment of Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China.
Wenzhao ZhongGuangdong Lung Cancer Institute, Guangdong Provincial Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, Guangzhou 510080, China.
Zhijie WangState Key Laboratory of Molecular Oncology, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Shengxiang RenDepartment of Medical Oncology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China.
Wenfeng FangDepartment of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Yongchang ZhangDepartment of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China.
Jingjing LiuDepartment of Thoracic Cancer, Jilin Cancer Hospital, Changchun 130012, China.
Xiuyu CaiDepartment of VIP Inpatient, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Anwen LiuDepartment of Oncology, Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Wen LiKey Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Cancer Center, Zhejiang University, Hangzhou 310009, China.
Ping ZhanDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
Hongbing LiuDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
Tangfeng LvDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
Liyun MiaoDepartment of Respiratory Medicine, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China.
Lingfeng MinDepartment of Respiratory Medicine, Clinical Medical School of Yangzhou University, Subei People's Hospital of Jiangsu Province, Yangzhou 225001, China.
Yu ChenDepartment of Medical Oncology, Fujian Medical University Cancer Hospital & Fujian Cancer Hospital, Fuzhou 350014, China.
Yu ZhangDepartment of Oncology, Guizhou Provincial People's Hospital, Guiyang 550001, China.
Feng WangDepartment of Internal Medicine, Cancer Center of PLA, Qinhuai Medical Area, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
Zhansheng JiangDepartment of Integrative Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
Gen LinDepartment of Medical Oncology, Fujian Medical University Cancer Hospital & Fujian Cancer Hospital, Fuzhou 350014, China.
Long HuangDepartment of Oncology, Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Xingxiang PuThe Second Department of Thoracic Oncology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China.
Rongbo LinDepartment of Medical Oncology, Fujian Medical University Cancer Hospital & Fujian Cancer Hospital, Fuzhou 350014, China.
Weifeng LiuDepartment of Orthopedic Oncology Surgery, Beijing Ji shui tan Hospital, Peking University, Beijing 100035, China.
Chuangzhou RaoDepartment of Radiotherapy and Chemotherapy, Hwamei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China.
Dongqing LvDepartment of Pulmonary Medicine, Taizhou Hospital of Wenzhou Medical University, Taizhou 317000, China.
Zongyang YuDepartment of Respiratory Medicine, the 900th Hospital of the Joint Logistics Team (the Former Fuzhou General Hospital), Fujian Medical University, Fuzhou 350025, China.
Peng ShenDepartment of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Xiaoyan LiDepartment of Oncology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100700, China.
Chuanhao TangDepartment of Medical Oncology, Peking University International Hospital, Beijing 102206, China.
Chengzhi ZhouState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510300, China.
Junping ZhangDepartment of Thoracic Oncology, Shanxi Academy of Medical Sciences, Shanxi Bethune Hospital, Taiyuan 030032, China.
Junli XueDepartment of Oncology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200123, China.
Hui GuoDepartment of Oncology, The Second Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710004, China.
Qian ChuDepartment of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Rui MengCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Jingxun WuDepartment of Medical Oncology, The First Affiliated Hospital of Medicine, Xiamen University, Xiamen 361003, China.
Rui ZhangDepartment of Medical Oncology, Cancer Hospital of China Medical University, Shenyang 110042, China.
Jin ZhouDepartment of Medical Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology, Chengdu 610041, China.
Zhengfei ZhuDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Yongheng LiKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Hong QiuDepartment of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Fan XiaDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Yuanyuan LuState Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an 710032, China.
Xiaofeng ChenDepartment of Oncology, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Nanjing 210029, China.
Rui GeDepartment of General Surgery, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China.
Enyong DaiDepartment of Oncology and Hematology, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
Yu HanDepartment of Gastrointestinal Oncology, Harbin Medical University Cancer Hospital, Harbin 150081, China.
Jian ZhangDepartment of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Yinghua JiDepartment of Oncology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453000, China.
Xianbin LiangDepartment of Oncology, The Third People's Hospital of Zhengzhou, Zhengzhou 450000, China.
Hongmei ZhangDepartment of Biotherapy, State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Xuelei MaDepartment of Biotherapy, State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Xuewen LiuDepartment of Oncology, the Third Xiangya Hospital, Central South University, Changsha 410013, China.
Yu YaoDepartment of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Peng LuoDepartment of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Weiwei PanDepartment of Cell Biology, College of Medicine, Jiaxing University, Jiaxing 314001, China.
Fei PangDepartment of Medical, Shanghai OrigiMed Co, Ltd, Shanghai 201114, China.
Fan WuDepartment of Medical, Menarini Silicon Biosystems SpA, Shanghai 200333, China.
Dejian GuDepartment of Medical, Geneplus-Beijing, Beijing 102200, China.
Li WangDepartment of Medical, Geneplus-Beijing, Beijing 102200, China.
Liping WangDepartment of Oncology, Baotou Cancer Hospital, Baotou 014000, China.
Youcai ZhuDepartment of Thoracic Disease Diagnosis and Treatment Center, Zhejiang Rongjun Hospital, The Third Affiliated Hospital of Jiaxing University, Jiaxing 314000, China.
Li LinDepartment of Medical Oncology, Peking University International Hospital, Beijing 102206, China.
Weiwen LiDepartment of Oncology, Lishui Municipal Central Hospital, Lishui 323000, China.
Xinqing LinState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510300, China.
Jing CaiDepartment of Oncology, Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Ling XuDepartment of Interventional Pulmonary Diseases, Anhui Chest Hospital, Hefei 230011, China.
Jisheng LiDepartment of Medical Oncology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Xiaodong JiaoDepartment of Medical Oncology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200070, China.
Kainan LiDepartment of Oncology, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250031, China.
Jia WeiDepartment of The Comprehensive Cancer Center, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China.
Huijing FengDepartment of Thoracic Oncology, Shanxi Academy of Medical Sciences, Shanxi Bethune Hospital, Taiyuan 030032, China.
Lin WangDepartment of Pathology, Shanxi Academy of Medical Sciences, Shanxi Bethune Hospital, Taiyuan 030032, China.
Yingying DuDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Wang YaoDepartment of Interventional Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510060, China.
Xuefei ShiDepartment of Respiratory Medicine, Huzhou Hospital, Zhejiang University School of Medicine, Huzhou 313000, China.
Xiaomin NiuDepartment of Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China.
Dongmei YuanDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
Yanwen YaoDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
Yinbin ZhangDepartment of Oncology, The Second Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710004, China.
Binbin SongDepartment of Medical Oncology, The Affiliated Hospital of Jiaxing University, Jiaxing 314000, China.
Wenfeng LiDepartment of Radiation Oncology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Jianfei FuDepartment of Medical Oncology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua 321000, China.
Hong WangSenior Department of Oncology, The 5th Medical Center of PLA General Hospital, Beijing 100071, China.
Mingxiang YeDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
Dong WangDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
Zhaofeng WangDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
Qing JiDepartment of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou 310022, China.
Yuan FangDepartment of Pathology, Anhui Provincial Children's Hospital, Hefei 230051, China.
Qing WeiDepartment of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou 310022, China.
Zhen WangDepartment of Radiation Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
Bin WanDepartment of Respiratory Medicine, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 210002, China.
Donglai LvDepartment of Clinical Oncology, The 901 Hospital of Joint Logistics Support Force of People Liberation Army, Hefei 230031, China.
Xiaofeng LiDepartment of Thoracic Disease Diagnosis and Treatment Center, Zhejiang Rongjun Hospital, The Third Affiliated Hospital of Jiaxing University, Jiaxing 314000, China.
Shengjie YangDepartment of Thoracic Surgery, Chuxiong Yi Autonomous Prefecture People's Hospital, Chuxiong 675000, China.
Jing KangGuangdong Lung Cancer Institute, Guangdong Provincial Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, Guangzhou 510080, China.
Jiatao ZhangGuangdong Lung Cancer Institute, Guangdong Provincial Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, Guangzhou 510080, China.
Chao ZhangGuangdong Lung Cancer Institute, Guangdong Provincial Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, Guangzhou 510080, China.
Lin ShiDepartment of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Yina WangDepartment of Oncology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310000, China.
Bihui LiDepartment of Oncology, The Second Affiliated Hospital of Guilin Medical University, Guilin 541199, China.
Zhang ZhangInternational Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE), Guangzhou City Key Laboratory of Precision Chemical Drug Development, School of Pharmacy, Jinan University, Guangzhou 510632, China.
Ke WangNational Health Commission (NHC) Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China.
Zhefeng LiuSenior Department of Oncology, The 5th Medical Center of PLA General Hospital, Beijing 100071, China.
Nong YangDepartment of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China.
Lin WuThe Second Department of Thoracic Oncology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China.
Xiaobing ChenDepartment of Oncology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China.
Gu JinDepartment of Bone and Soft-tissue Surgery, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou 310022, China.
Zhongwu LiKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Pathology, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Miao LiDepartment of Oncology, The Cancer Hospital of Qinghai Province, Xining 810001, China.
Guansong WangInstitute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Jiandong WangDepartment of Pathology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
Meiyu FangDepartment of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou 310022, China.
Yong FangDepartment of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China.
Xiaojia WangDepartment of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou 310022, China.
Jing ChenCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Yiping ZhangDepartment of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou 310022, China.
Xixu ZhuDepartment of Radiation Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
Yi ShenDepartment of Thoracic Surgery, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
Shenglin MaDepartment of Oncology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou Cancer Hospital, Cancer Center, Westlake University School of Medicine, Hangzhou 310006, China.
Biyun WangDepartment of Breast Cancer and Urological Medical Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Lu SiKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Melanoma and Sarcoma, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Yong SongDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
Yuanzhi LuDepartment of Clinical Pathology, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.ORCID 0000-0003-2946-643X
Aijun LiuSenior Department of Pathology, the 7th Medical Center of PLA General Hospital, Beijing 100700, China.
Yuchen HanDepartment of Pathology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China.ORCID 0000-0002-2548-5492
Funding
International Medical Association IMA-F-2025-001National Natural Science Foundation of China 82072577
Abstract
As an emerging biomarker, tumor mutational burden (TMB) has attracted increasing attention from clinicians in predicting the efficacy of tumor immunotherapy. Currently, TMB is detected primarily by whole-exome sequencing or targeted panel sequencing on high-throughput sequencing platforms. However, the lack of uniformity in detection methods, threshold settings, and reporting formats, as well as the significant differences in TMB values among different cancer types, have hindered the standardized application of this biomarker in clinical practice. This consensus focuses on the definition, standardization of detection, clinical significance, and limitations of TMB, and provides consensus recommendations for the clinical application of TMB in real-world practice in China. This consensus is aimed at helping clinicians and laboratory personnel understand the clinical significance and testing standards of TMB, promoting more accurate interpretation of test results, and improving patient care.
Indexed as
Biomarkers, TumorMutationNeoplasmsTumor BurdenDNA Mutational AnalysisExome SequencingHigh-Throughput Nucleotide SequencingHumansImmunotherapyBiomarkers, TumorBiomarkerstargeted panel sequencingtumor immunotherapytumor mutational burdenwhole-exome sequencing
Identifiers
What Socratic holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.