Evidence map›Paper›PMID 41704162›Full record

ArticleThe FEBS journal2026

The malate-aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes.

Michaela Veliova, Caroline M Ferreira, Katrina P Montales, Francisco Villalobos, Alexandra J Brownstein, Rebeca Acín-Pérez, Gabrielly S Ferreira, Anthony E Jones, Linsey Stiles, Ajit S Divakaruni and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The FEBS journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Michaela VeliovaDepartment of Molecular and Medical Pharmacology, and Division of Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, USA.ORCID https://orcid.org/0000-0003-1117-691X
Caroline M FerreiraDepartment of Molecular and Medical Pharmacology, and Division of Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, USA.
Katrina P MontalesDepartment of Molecular and Medical Pharmacology, and Division of Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, USA.
Francisco VillalobosDepartment of Molecular and Medical Pharmacology, and Division of Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, USA.
Alexandra J BrownsteinDepartment of Molecular and Medical Pharmacology, and Division of Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, USA.
Rebeca Acín-PérezDepartment of Molecular and Medical Pharmacology, and Division of Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, USA.
Gabrielly S FerreiraInstitute of Medical Biochemistry Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Brazil.
Anthony E JonesDepartment of Molecular and Medical Pharmacology, and Division of Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, USA.
Linsey StilesDepartment of Molecular and Medical Pharmacology, and Division of Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, USA.
Ajit S DivakaruniDepartment of Molecular and Medical Pharmacology, and Division of Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, USA.
Marc LiesaDepartment of Molecular and Medical Pharmacology, and Division of Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, USA.
Orian S ShirihaiDepartment of Molecular and Medical Pharmacology, and Division of Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, USA.ORCID https://orcid.org/0000-0001-8466-3431
Marcus F OliveiraInstitute of Medical Biochemistry Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-9890-8425

Funding

Agencia Estatal de Investigación 10.13039/501100011033Agencia Estatal de Investigación PID2021-127278NB-I00CLC NIH HHS 5-RO1DK099618-02Conselho Nacional de Desenvolvimento Científico e Tecnológico 141311/2016-9Conselho Nacional de Desenvolvimento Científico e Tecnológico 229526/2013-6Conselho Nacional de Desenvolvimento Científico e Tecnológico 303044/2017-9Conselho Nacional de Desenvolvimento Científico e Tecnológico 308629/2021-3Conselho Nacional de Desenvolvimento Científico e Tecnológico 404153/2016-0Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88881.187835/2018-01Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro 26/102.333/2013Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/203.043/2016Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/210.409/2019
6 · The paper itself

Abstract

Brown adipose tissue (BAT) plays a central role in thermogenesis by coupling fatty acid oxidation to heat production. Efficient BAT thermogenic activity requires enhanced glycolytic flux, which in turn depends on continuous regeneration of cytosolic NAD

Indexed as

Adipocytes, BrownAspartic AcidLipid MetabolismMalatesThermogenesisAdipose Tissue, BrownAmino Acid Transport Systems, AcidicAnimalsAntiportersEnergy MetabolismMalate DehydrogenaseMembrane Transport ProteinsMiceMitochondriaNADOxidation-ReductionAmino Acid Transport Systems, AcidicAntiportersaspartate-glutamate carrierAspartic AcidMalate Dehydrogenasemalic acidMembrane Transport ProteinsNADoxoglutarate translocatorenergyheatmetabolismobesityredoxthermogenesis

Identifiers

PMID41704162
PMCPMC13440609

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.