Evidence map›Paper›PMID 41704231›Full record

ArticleBioactive materials2026

Pre-priming cell sheet therapy enabled by dynamic wrinkled electroactive substrate for muscle reconstruction.

Chunyi Pu, Siyu Liang, Yue Ma, Xingyun Fan, Jin Li, Jingyu Guan, Rurong Lin, Shuai Liu, Jie Zhang, Dong Yang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chunyi PuGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Science, Southern Medical University, Guangdong, Guangzhou, 510515, China.
Siyu LiangGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Science, Southern Medical University, Guangdong, Guangzhou, 510515, China.
Yue MaGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Science, Southern Medical University, Guangdong, Guangzhou, 510515, China.
Xingyun FanGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Science, Southern Medical University, Guangdong, Guangzhou, 510515, China.
Jin LiSchool of Chemistry & Chemical Engineering, Frontiers Science Center for Transformative Molecules, State Key Laboratory for Metal Matrix Composite Materials, Shanghai Jiao Tong University, Shanghai, 200240, China.
Jingyu GuanGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Science, Southern Medical University, Guangdong, Guangzhou, 510515, China.
Rurong LinGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Science, Southern Medical University, Guangdong, Guangzhou, 510515, China.
Shuai LiuGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Science, Southern Medical University, Guangdong, Guangzhou, 510515, China.
Jie ZhangGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Science, Southern Medical University, Guangdong, Guangzhou, 510515, China.
Dong YangKey Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.
Xuesong JiangSchool of Chemistry & Chemical Engineering, Frontiers Science Center for Transformative Molecules, State Key Laboratory for Metal Matrix Composite Materials, Shanghai Jiao Tong University, Shanghai, 200240, China.
Xiaozhong QiuGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Science, Southern Medical University, Guangdong, Guangzhou, 510515, China.
Honghao HouGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Science, Southern Medical University, Guangdong, Guangzhou, 510515, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current therapeutic approaches for muscle reconstruction face considerable challenges, particularly in generating sufficiently dense cell aggregates and in establishing effective methods for reactivating the function of exogenous cells. Herein, we developed a pre-priming cell sheet therapy for volumetric muscle loss (VML) that leverages highly dense, electro-mechanically bioactive constructs. To achieve this goal, we fabricated a multifunctional cell culture platform based on a near-infrared (NIR)-responsive, wrinkle-patterned, conductive substrate. This system enables scalable preparation (>6 mm in diameter), non-invasive harvesting, and bioactive pre-priming of cell sheets for transplantation. Non-invasive harvesting of the sheets is achieved via a NIR-triggered release mechanism, in which dynamic changes in wrinkle morphology induce a sufficient shift in mechanical stress at the cell-substrate interface, thereby disrupting focal adhesions. Compared with conventional cell-suspension therapy, the microstructured electroactive surface demonstrated superior efficacy for VML repair, as evidenced by integrated in vitro electrophysiology, RNA sequencing, and

Indexed as

Cell sheetDynamic wrinkleMuscle injury repairTunable cell adhesionVolumetric muscle loss

Identifiers

PMID41704231
PMCPMC12907012

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.