ArticleMaterials today. Bio2026
A dual-functional Janus nanofibrous membrane as an immunomodulatory barrier for periodontitis regeneration under diabetic conditions.
Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Strontium-incorporated thermoresponsive hydrogel platform co-delivering graphene oxide-mannose nanocomplexes: An osteoimmunomodulatory strategy for periodontitis therapy.Materials today. Bio · 2026Article
- Design and applications of barrier membranes for guided bone regeneration.Bioactive materials · 2026Review
- Application and Potential of Local Drug Delivery Systems for Antibacterial Treatment of Periodontitis.International journal of molecular sciences · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontitis and diabetes mellitus exhibit a well-established bidirectional relationship, creating a hostile microenvironment characterized by persistent inflammation, oxidative stress, and impaired osteogenesis. Conventional guided tissue regeneration (GTR) membranes often yield suboptimal regenerative outcomes under these diabetic conditions due to their passive, monolithic structure. To address this limitation, we developed a novel dual-functional bilayer nanofibrous membrane, termed Pn@Janus TPP, through rational structural design specifically tailored for diabetic periodontitis. This Janus membrane features an anisotropic architecture: a dense barrier layer effectively blocks the infiltration of fast-proliferating soft tissue cells, while an opposite porous layer is functionalized with a polyethylene glycol (PEG) hydrogel incorporated with nano-hydroxyapatite (nHA) to enhance hydrophilicity, sustained Ca
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.