ArticleFrontiers in microbiology2026
Effect of equine-derived
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
Funding
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Abstract
Introduction: This study aimed to evaluate the effects of equine-derived Methods: Specific pathogen-free (SPF) female KM mice were randomly assigned to a blank control group (BC) and three intervention groups (M11-L, M11-M, M11-H). The intervention groups received daily gavage of M11 at low (1.0 × 10 Results: (1) Host Physiology and Biochemistry: The M11-H group exhibited a significant elevation in albumin (ALB; 40.30 ± 1.75 g/L), suggesting enhanced nutritional status or hepatic protein synthesis. The M11-L group showed transient increases in alanine aminotransferase (ALT; 59.57 ± 10.34 U/L) and total cholesterol (TC; 2.90 ± 0.24 mmol/L), indicative of adaptive hepatic lipid metabolism. (2) Microbial Community Reconfiguration: Metagenomic analysis revealed significant structural shifts in the gut microbiota between the BC and M11-H groups. Notably, the M11-H group showed enrichment of Bacillota, which correlated with "O-antigen nucleotide sugar biosynthesis," while differences in Pseudomonadota were associated with immune regulation. (3) Metabolomic Profiling: Partial Least Squares Discriminant Analysis (PLS-DA) demonstrated clear separation in the cecal metabolome space. KEGG pathway enrichment analysis highlighted significant alterations in "glycine/serine/threonine metabolism" and "arginine/proline metabolism" pathways. (4) Integrated Multi-Omics Analysis: Correlation analysis identified a significant positive association between Discussion: The results demonstrate that
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